Environmental bisphenol exposure, infant brain and behavior: Human and animal models
环境双酚暴露、婴儿大脑和行为:人类和动物模型
基本信息
- 批准号:10260560
- 负责人:
- 金额:$ 63.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-10 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAnimal ModelAnimalsAnxietyAttentionAttention deficit hyperactivity disorderAuditoryBehaviorBehavioralBiometryBirthBrainCaringChildCodeCognitionCognitiveCollaborationsDNA MethylationDataDetectionDevelopmentElectroencephalographyEmotionalEndocrine DisruptorsEnvironmentEnvironmental HealthEpigenetic ProcessEvent-Related PotentialsExposure toFetusFollow-Up StudiesFosteringFrequenciesFundingFutureGene ExpressionGoalsHormonalHumanImpairmentIndividual DifferencesInfantInfant DevelopmentInfrastructureInterventionKnowledgeLeadLifeLinkLiteratureMaternal BehaviorMeasurementMeasuresMediatingMedical centerMethodsMidbrain structureModelingMolecularMolecular StructureMothersN-Methyl-D-Aspartate ReceptorsNervous System PhysiologyNeuraxisNeurodevelopmental DeficitNeurodevelopmental DisorderNeurosciencesNeurosecretory SystemsNeurotoxinsOutcomePathway interactionsPregnant WomenPrimatesRiskRodentRodent ModelRoleSchool-Age PopulationScienceScreening procedureSensorySensory ProcessSignal TransductionSocial BehaviorSocial DevelopmentStructureTestingTexasTimeTranslatingUniversitiesVariantVisualage relatedanaloganxiety-like behaviorattentional modulationaustinbisphenol Abrain behaviorcaregivingcognitive developmentcognitive functioncohortconsumer productcostdensitydopaminergic neuronexperimental studyexposed human populationfetalhuman modelimprovedin uteroindexingmaternal caregivingmultisensoryneural circuitneural correlateneurobehavioralneurodevelopmentneurodevelopmental effectneuroimagingneurophysiologyneurotoxicologynoveloffspringpostnatalprenatal exposurepublic health interventionreceptor bindingrecruitrelating to nervous systemsocial organizationtranslational approachvirtual
项目摘要
In utero bisphenol A (BPA) exposure disturbs neurobehavioral development in animals and in humans. The
pathways linking in utero BPA exposure to neurobehavioral development likely involve direct effects in utero on
infant brain development, and indirect effects via disruption of postnatal mother-infant interactions. Parental
social behaviors may be especially vulnerable to endocrine-disrupting chemicals such as BPA as these
behaviors are shaped by hormonal priming and by the organization of the social/parental brain. Most of the
human literature identifies effects of BPA in older children, with little focus on the first year of life. In rodent and
primate models, in utero exposure to BPA disrupts offspring cognitive and social development and maternal care
via epigenetic changes. In humans, the direct effect of BPA on infant brain development and attention, and the
modulation of these effects by BP-induced changes to mother-infant interaction, have not been examined. We
thus do not know the pathways through which BPA may disrupt development. Although BPA has been removed
from many consumer products, it has been replaced by structural analogs, bisphenol-s (BPS) and bisphenol-f
(BPF), which may have similar detrimental effects. This study will: 1) examine associations between in utero BP
(combined exposure) exposure and infant brain function and attention, 2) conduct a parallel rodent study of the
effects of in utero BP exposure on cellular and molecular changes in the brain, and 3) translate a human method
of studying mother-infant interaction for use in our rodent model and determine the effects of BP on these
caregiving interactions. In both humans and rodents, we ask whether associations detected between in utero BP
and brain and cognitive development are moderated by BP-induced change in mother-infant interaction. In our
translational approach, we recruit infants at 1- and 9-months old and assess infant brain function and attention
at two timepoints, and we leverage previously funded measurement of mother-infant interaction to test its
moderating effects on these associations. In our parallel rodent model, we measure effects of BP exposure on
offspring cortical gene expression, structure, attention and quality of mother-infant interactions.
Impact: This R01 addresses a critical gap in our understanding of how in utero exposure to endocrine-disrupting
chemicals alters infant brain and cognitive function. Understanding these effects is essential to developing
screening tools and intervention for downstream effects on neurodevelopment. The R01 also provides
preliminary data for use in future translational collaborations among this team. Future animal studies will
disentangle the direct and indirect effects of BP through cross-fostering experiments, and human studies will
follow this cohort into school age to investigate neural correlates of BP-induced effects on neurodevelopment.
在子宫内暴露于双酚A (BPA)会扰乱动物和人类的神经行为发育。的
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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AMY MARGOLIS其他文献
AMY MARGOLIS的其他文献
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{{ truncateString('AMY MARGOLIS', 18)}}的其他基金
Environmental Contributions to Disparities in Learning Disabilities: The Columbia Psychiatry, Psychology, and Public Health Collaborative Learning Disabilities Innovation Hub
环境对学习障碍差异的影响:哥伦比亚精神病学、心理学和公共卫生合作学习障碍创新中心
- 批准号:
10533147 - 财政年份:2022
- 资助金额:
$ 63.96万 - 项目类别:
Effects of Prenatal Exposure to Air Pollution and Early Life Stress on Dopaminergic and Cognitive Systems and Their Contributions to Environmentally-Associated Learning Difficulties
产前空气污染暴露和早期生活压力对多巴胺能和认知系统的影响及其对环境相关学习困难的影响
- 批准号:
10533148 - 财政年份:2022
- 资助金额:
$ 63.96万 - 项目类别:
Prenatal Environmental Mixtures, Cognitive Control and Reward Processes, And Risk for Psychiatric Problems in Adolescence.
产前环境混合物、认知控制和奖励过程以及青春期精神问题的风险。
- 批准号:
10303872 - 财政年份:2021
- 资助金额:
$ 63.96万 - 项目类别:
Prenatal Exposure to Environmental Tobacco Smoke, COVID-19- Related Psychosocial Stress, and Neurodevelopment.
产前暴露于环境烟草烟雾、与 COVID-19 相关的社会心理压力和神经发育。
- 批准号:
10282859 - 财政年份:2021
- 资助金额:
$ 63.96万 - 项目类别:
Prenatal Environmental Mixtures, Cognitive Control and Reward Processes, And Risk for Psychiatric Problems in Adolescence.
产前环境混合物、认知控制和奖励过程以及青春期精神问题的风险。
- 批准号:
10657608 - 财政年份:2021
- 资助金额:
$ 63.96万 - 项目类别:
Prenatal Environmental Mixtures, Cognitive Control and Reward Processes, And Risk for Psychiatric Problems in Adolescence.
产前环境混合物、认知控制和奖励过程以及青春期精神问题的风险。
- 批准号:
10473871 - 财政年份:2021
- 资助金额:
$ 63.96万 - 项目类别:
Environmental bisphenol exposure, infant brain and behavior: Human and animal models
环境双酚暴露、婴儿大脑和行为:人类和动物模型
- 批准号:
10393372 - 财政年份:2020
- 资助金额:
$ 63.96万 - 项目类别:
Environmental bisphenol exposure, infant brain and behavior: Human and animal models
环境双酚暴露、婴儿大脑和行为:人类和动物模型
- 批准号:
10461056 - 财政年份:2020
- 资助金额:
$ 63.96万 - 项目类别:
Environmental bisphenol exposure, infant brain and behavior: Human and animal models
环境双酚暴露、婴儿大脑和行为:人类和动物模型
- 批准号:
10064434 - 财政年份:2020
- 资助金额:
$ 63.96万 - 项目类别:
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