High throughput Sequencing Hub for the North of England

DNA序列一直是医学和临床研究进步的重要灵感来源。这在第一个人类基因组测序中达到高潮，这个项目花了6-8年时间和数十亿英镑。因此，我们能够发现决定人类形态的基因的数量和身份，尽管要弄清楚这些基因如何相互作用要花更长的时间。但我们知道，每个人对疾病的易感性不同，对治疗的反应也不同。目前的需要是了解这种差异的基础，并利用它来更充分地了解如何为患有特定疾病的特定患者确定最合适的治疗方法。这叫？个性化的药吗?人们普遍认为这是优化治疗的最佳方法。要做到这一点，就需要在这些病人身上建立特定基因的DNA序列，这就需要更高效的测序技术。幸运的是，现在有了新的仪器，可以在几周内对一个人进行大约10-5万美元的测序。位于利物浦的先进基因组学设施（AGF）是英国领先的卓越中心和新一代测序技术的服务提供商。我们希望扩大AGF的能力，为英格兰北部大学和医院的研究领导者提供一站式服务，为工作的各个阶段提供建议。我们还将提供培训和资助成本分摊计划，帮助客户群体将DNA序列转化为知识。

DNA sequence has always been an important source of inspiration for advances in medical and clinical research. This culminated in the sequencing of the first human genome, a project that took 6-8 years and several billion pounds. As a result we were able to discover the number and identity of genes that defined the human form though it is taking much longer to work out how these genes interact. But we know that people vary from each other in their disease susceptibility or in the way that they respond to treatment. The current need is to understand the basis of this variation and to use it to understand more fully how to define the most appropriate treatment to particular patients presenting with a particular condition. This is called ?personalised medicine? and it is widely thought to be the best way of optimising treatment.Achieving this requires establishing the DNA sequence of particular genes in those patients, and this requires much more productive sequencing technologies. Fortunately, new instruments are now becoming available which can sequence a human in just a few weeks for approx #10-50,000. The Advanced Genomics Facility (AGF), located in Liverpool, is a leading UK centre of excellence and service provider for the new generation of sequencing technologies. We want to expand the capacity of the AGF to serve the research leaders in Universities and hospitals of the North of England by offering a one-stop shop that provides advice for all stages of the work. We shall also provide training and pump-prime cost-sharing programmes helping client groups to turn DNA sequence into knowledge.