Centre for Genomic Research: Genomics Hub Renewal

在过去的5年里，分子生物学已经被新的测序技术的应用所改变。这些技术使DNA和RNA的测序速度比以前快得多，成本也大大降低。这些发展为在MRC职权范围内工作的研究人员创造了机会。因此，MRC在2009年资助了四个测序中心，其中一个是利物浦基因组研究中心（CGR）。CGR有许多不同的收入来源。它接受MRC和自然与环境研究委员会（NERC）的资助，通过其生物分子分析设施，为各自权限内的小组提供协作服务。该设施还受益于利物浦大学在员工工资和设备购买方面的支持。CGR还通过向学术合作伙伴或商业客户收取项目费用来产生收入。此外，CGR的联合主任还持有一些赠款，因此CGR既是一个研究实验室，也是一个服务实验室。我们将通过向合作伙伴和客户收取全部费用，使CGR的服务运营在未来3年内实现财务自给自足。该申请寻求未来两年的资金，但将以大幅降低的费率完成CGR向财务自我可持续性的过渡。为了实现这一演变，CGR将继续其目前的工作，但也将实施一些新的举措。我们将扩大和发展CGR的设备，以跟上吞吐量和成本的进步。2. 我们将雇用一名业务经理，以扩大我们的市场范围。我们将举办一系列针对MRC研究界的培训活动，向生物医学研究人员介绍基因组技术、分析方法和高通量测序数据的应用。为了扩大我们在MRC研究社区的影响力，我们将提供第二次激励竞赛，允许与MRC相关的申请人以最低的成本在CGR设施内进行试验或技术开发项目。

Over the last 5 years molecular biology has been transformed by the application of new sequencing technologies. These technologies allow DNA and RNA to be sequenced much faster than was previously possible and at a significantly reduced cost. These developments create opportunities for researchers working within the MRC remit. Hence, the MRC funded four sequencing hubs in recognition of this in 2009, one of which is the Liverpool Centre for Genomic Research (CGR).The CGR has a number of different income streams. It receives funding from the MRC and the Natural and Environmental Research Council (NERC), via its Biomolecular Analysis Facility, to provide collaborative services to groups working within the respective remits. The facility has also benefited from support by the University of Liverpool for staff salaries and equipment purchases. The CGR also as generates income by re-charging project costs from academic collaborators or commercial clients. In addition, the CGR co-directors hold a number of grants and hence the CGR is both a research lab and a service lab. We will make the service operation of the CGR become financially self-sustaining over the next 3 years by recharging the full cost to collaborators and clients.This application seeks funding for a further two years but at a substantially reduced rate that will complete the transition of the CGR to financial self-sustainability. To enable this evolution, the CGR will continue its current work but also put in place a number of new initiatives.1. We will expand and develop the equipment in the CGR to keep up with advances in throughput and cost. 2. We will focus on expanding our market reach by hiring a Business Manager.3. We will present a number of training events aimed at the MRC research community to inform biomedical researchers on genomic technologies, analytical methods and applications of high-throughput sequencing data.4. To expand our reach into the MRC research community we will offer a second pump-priming competition to allow MRC-linked applicants to undertake trial or technology development projects within the CGR facility at minimal cost.