Dissecting the mechanism of action of the renin angiotensin hormone angiotensin1-9

剖析肾素血管紧张素激素 angiotensin1-9 的作用机制

• 批准号: G0901161/1
• 负责人: Stuart Nicklin
• 金额: $ 48.87万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0901161%2F1
• 关键词: Dissecting; mechanism; action; renin; angiotensin

The body produces specific hormones which travel via the bloodstream and engage with receptors which contribute to the normal function of blood vessels, the heart and kidney. The main hormone from this system, angiotensin II, can become overactive and contribute to the development of cardiovascular disease, resulting in high blood pressure (hypertension) and finally enlargement of the heart and damage to kidneys. Although this has been known for a long time (in fact inhibitors of various facets of angiotensin II function are the target for a common group of drugs used to lower blood pressure in patients and treat conditions such as heart failure) the central mechanisms for the functioning of this hormone system are not completely understood. The hormone system has many different roles in the body depending upon the organ on which it acts. Also, new members of this hormone family are being discovered. Here we describe a role for a new hormone in this system, angiotensin 1-9. Angiotensin 1-9 was previously thought to be inactive but we have evidence to support it being an active hormone which inhibits angiotensin II actions. Thus angiotensin 1-9 may be an important therapeutic target in cardiovascular disease. We wish to full understand how this hormone functions and will achieve this using a range of techniques.

身体产生特定的激素，这些激素通过血流传播并与有助于血管、心脏和肾脏正常功能的受体结合。该系统的主要激素血管紧张素 II 可能变得过度活跃，导致心血管疾病的发展，导致高血压，最终导致心脏扩大和肾脏受损。尽管这一点早已为人所知（事实上，血管紧张素 II 功能的各个方面的抑制剂是用于降低患者血压和治疗心力衰竭等疾病的一组常见药物的目标），但该激素系统功能的中心机制尚未完全了解。激素系统在​​体内具有许多不同的作用，具体取决于其作用的器官。此外，该激素家族的新成员正在被发现。在这里，我们描述了该系统中一种新激素血管紧张素 1-9 的作用。血管紧张素 1-9 以前被认为是无活性的，但我们有证据支持它是一种抑制血管紧张素 II 作用的活性激素。因此血管紧张素1-9可能是心血管疾病的重要治疗靶点。我们希望充分了解这种激素的功能，并将使用一系列技术来实现这一目标。