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Angiotensin-(1-7) and angiotensin-(1-9): assessment as therapeutic targets in acute vascular injury and remodelling

血管紧张素-(1-7) 和血管紧张素-(1-9)：作为急性血管损伤和重塑治疗靶点的评估

基本信息

批准号：
MR/L019108/1
负责人：
Stuart Nicklin
金额：
$ 45.61万
依托单位：
University of Glasgow
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2014
资助国家：
英国
起止时间：
2014 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=MR%2FL019108%2F1
关键词：
Angiotensin angiotensin assessment therapeutic targets

项目摘要

Heart disease is commonly caused by the buildup of fat or plaques in blood vessels that deliver blood to the heart, causing them to become blocked. To unblock blood vessels doctors use two approaches, in one a balloon is inserted into the blockage and inflated to clear it and in another a piece of vein is removed from the patients leg and implanted into the heart to bypass the blockage. Both approaches are effective to treat the patients, however damage to the blood vessel by the inflated balloon or to the vein used to bypass the blockage by the high blood pressure in the heart cause these treatments to fail, by triggering overgrowth of the blood vessels causing them to become blocked again. Currently, there is a need for new treatments to prevent this failure. We have identified a new potential therapeutic target that may be able to prevent this overgrowth. The body produces specific hormones which travel via the bloodstream and engage with receptors which contribute to the normal function of blood vessels, the heart and kidney. The main hormone from this system, angiotensin II, can become overactive and contribute to the development of cardiovascular diseases, including the adverse vascular overgrowth which blocks blood vessels. We have identified an alternative hormone in this pathway which can block the growth of the cells in blood vessels and potentially prevent the vessels from becoming blocked. Here, we will investigate this hormone more fully to understand how it functions and to test whether it has therapeutic benefit in animal models of vessel blockage. This will help us understand the function better and highlight whether it is a suitable molecular to develop into a therapeutic drug in the future.

心脏病通常是由脂肪或斑块在向心脏输送血液的血管中积聚引起的，导致血管阻塞。为了疏通血管，医生们使用了两种方法，一种是将一个气球插入堵塞处并充气以清除堵塞，另一种是从病人的腿上取出一段静脉并植入心脏以绕过堵塞。这两种方法对治疗患者都是有效的，然而，通过膨胀的球囊对血管的损伤或通过心脏中的高血压对用于绕过堵塞的静脉的损伤导致这些治疗失败，通过触发血管的过度生长导致它们再次堵塞。目前，需要新的治疗方法来防止这种失败。我们已经确定了一个新的潜在的治疗目标，可能能够防止这种过度生长。身体产生特定的激素，这些激素通过血液流动并与有助于血管、心脏和肾脏正常功能的受体结合。来自该系统的主要激素血管紧张素II可以变得过度活跃并有助于心血管疾病的发展，包括阻塞血管的不良血管过度生长。我们已经确定了这一途径中的替代激素，它可以阻止血管中细胞的生长，并可能防止血管阻塞。在这里，我们将更全面地研究这种激素，以了解它是如何发挥作用的，并测试它是否在血管阻塞的动物模型中具有治疗益处。这将有助于我们更好地了解功能，并突出它是否是未来开发成治疗药物的合适分子。