An interactive in vivo and molecular investigation of the arrhythmogenic mechanisms of sudden cardiac death

心源性猝死心律失常机制的交互式体内和分子研究

• 批准号: G0901819/1
• 负责人: Pier Lambiase
• 金额: $ 102.35万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0901819%2F1
• 关键词: interactive; vivo; molecular; investigation; arrhythmogenic

Sudden cardiac arrest (SCA) claims over 300,000 lives per year in the U.S. alone. Prior to cardiac arrest alternating changes on the surface heart tracing (ECG) occur which are thought to arise from fluctuations in the electrical activity on the outside of the heart. These fluctuations are initially in synch with one another (concordant alternans) and then become out of synch (discordant alternans) before degenerating into ventricular fibrillation (VF). Although animal studies have demonstrated this, it has not been possible to study these events in man. We have developed a unique strategy to investigate these changes in patients undergoing open heart surgery. Using data from these measurements we will be able to better understand how and why dangerous rhythms develop. This will lead to improvements in identifying people at the greatest risk of sudden death and allow us to create computer models of electrical activity in the heart. This will aid the development of new treatments in these patients.

仅在美国，每年就有30多万人死于心脏骤停(SCA)。在心脏骤停之前，心脏表面会发生交替变化，这被认为是由于心脏外部电活动的波动引起的。这些波动最初彼此同步(和谐交替)，然后变得不同步(不协调交替)，然后退化为室颤(VF)。虽然动物研究已经证明了这一点，但还不可能在人类身上研究这些事件。我们开发了一种独特的策略来调查接受心脏直视手术的患者的这些变化。使用这些测量数据，我们将能够更好地了解危险的节律是如何以及为什么发生的。这将在识别猝死风险最大的人方面有所改进，并使我们能够创建心脏电活动的计算机模型。这将有助于这些患者开发新的治疗方法。