Functional anatomy of cognitive training using chunking in working memory in Alzheimers disease

阿尔茨海默病是一种以记忆障碍为特征的毁灭性疾病。？工作记忆吗?在短时间内记忆信息的能力在疾病早期就受到影响。我正在研究改善工作记忆的策略，比如分块记忆。分块是指将信息分组成块以提高记忆容量的能力。在一项初步研究中，我检查了早期阿尔茨海默病患者，发现在疾病的早期阶段，个体可以使用分块策略来改善他们的工作记忆。因此，我打算教患有早期阿尔茨海默病的患者分块策略。我将评估这是否能显著改善他们的工作记忆，并将使用脑成像来调查与组块训练相关的大脑活动的潜在变化。利用认知训练进行分块记忆可能是一种重要的治疗方法，可以帮助阿尔茨海默氏症患者保持记忆。

Alzheimer‘s disease is a devastating illness characterised by memory impairment. ?Working memory?, the ability to remember information over short periods of time, is affected early in the disease. I am investigating strategies to improve working memory, such as chunking. Chunking refers to the ability to group information together into chunks to improve memory capacity.In a pilot study I examined patients with early Alzheimer‘s disease and found that individuals at the very early stage of the disease can use chunking strategies to improve their working memory. I therefore intend to teach patients with early Alzheimer‘s disease chunking strategies. I will assess whether this significantly improves their working memory and will use brain imaging to investigate underlying changes in brain activity associated with training in chunking.Using cognitive training in chunking could prove an important therapeutic approach to preserving memory in individuals suffering from Alzheimer‘s disease.