Revealing functional networks and circuits of the posteromedial cortex withanatomical connectivity
揭示后内侧皮质的功能网络和回路与解剖学连接
基本信息
- 批准号:10875048
- 负责人:
- 金额:$ 37.53万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-05 至 2024-10-31
- 项目状态:已结题
- 来源:
- 关键词:AnatomyAnxietyAreaArousalAttentionAxonBiologicalBiologyBrainBrain regionCellsCognitiveComplexCorpus striatum structureDataDeep Brain StimulationDiffusion Magnetic Resonance ImagingDiseaseDorsalEtiologyFiberGoalsHumanImpaired cognitionIndividualInjectionsInterventionKnowledgeLabelLaboratoriesLinkMacaca mulattaMajor Depressive DisorderMapsMedialMental DepressionMental disordersMethodsNeuronsNon-Invasive DetectionPathway interactionsPatternPopulation ProjectionPositioning AttributePost-Traumatic Stress DisordersPredispositionPrefrontal CortexResearchResearch PersonnelRestRewardsRoleSchizophreniaScientistSelf PerceptionSocial Anxiety DisorderTemporal LobeTracerTranscranial magnetic stimulationVentral StriatumWorkbasecingulate cortexconnectomediffusion weightedexperimental studyimprovedneuralneuroimagingneuronal circuitryneuroregulationnonhuman primatepatient populationresponsewhite matter
项目摘要
Project Summary
The posteromedial cortex is a brain region that is especially abnormal in many psychiatric diseases,
including depression, schizophrenia, and anxiety. However, it has traditionally received little attention from
neuroscientists, in part because we do not understand its underlying biology. We propose to remedy this
problem by uncovering posteromedial cortical circuits using tract-tracing in nonhuman primates and diffusion-
weighted magnetic resonance imaging in nonhuman primates and humans. This pipeline will allow us to create
a segmentation of the posteromedial cortex according to its anatomical connectivity. First, we propose to tile
the nonhuman primate posteromedial cortex with tract-tracer injections, which will allow us to analyze its
connectivity with other, better-understood brain regions. We will use these data to segment the posteromedial
cortex according to its anatomical connectivity. We expect that different segments will connect with distinct,
well-defined networks within the brain. Next, we will collect diffusion-weighted neuroimaging data in nonhuman
primates and humans. Although this method allows noninvasive detection of some connections, it is highly
susceptible to errors. We will use the principles of white matter organization identified in the tract-tracing data
to guide and debug these neuroimaging data. Because tract-tracing cannot be performed in humans, this
pipeline offers a rare possibility to infer anatomical connectivity in the human brain. Finally, based on prior
neuroimaging experiments, scientists have hypothesized that the posteromedial cortex may connect with a
particularly large number of brain regions and networks. Thus, we would like to determine the extent of axonal
collateralization in the neurons of this brain region. In other words, does a single posteromedial cortical neuron
project to many other brain regions, or are the circuits largely separate? Together, we expect these projects
will elucidate PMC anatomical connectivity in such a way that large-scale neuroimaging networks can be linked
with specific neuronal circuits.
项目总结
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Prefrontal cortex and cognitive control: new insights from human electrophysiology.
前额皮质和认知控制:人类电生理学的新见解。
- DOI:10.12688/f1000research.20044.1
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Widge,AlikS;Heilbronner,SarahR;Hayden,BenjaminY
- 通讯作者:Hayden,BenjaminY
Retrosplenial Cortical Connectivity with Frontal Basal Ganglia Networks.
- DOI:10.1162/jocn_a_01699
- 发表时间:2021-05-01
- 期刊:
- 影响因子:3.2
- 作者:Monko ME;Heilbronner SR
- 通讯作者:Heilbronner SR
A structural and functional subdivision in central orbitofrontal cortex.
- DOI:10.1038/s41467-022-31273-9
- 发表时间:2022-06-24
- 期刊:
- 影响因子:16.6
- 作者:
- 通讯作者:
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Sarah Rachel Heilbronner其他文献
Sarah Rachel Heilbronner的其他文献
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{{ truncateString('Sarah Rachel Heilbronner', 18)}}的其他基金
Revealing functional networks and circuits of the posteromedial cortex with anatomical connectivity
揭示具有解剖连接性的后内侧皮质的功能网络和回路
- 批准号:
10292991 - 财政年份:2018
- 资助金额:
$ 37.53万 - 项目类别:
Revealing functional networks and circuits of the posteromedial cortex with anatomical connectivity
揭示具有解剖连接性的后内侧皮质的功能网络和回路
- 批准号:
10516723 - 财政年份:2018
- 资助金额:
$ 37.53万 - 项目类别:
Revealing functional networks and circuits of the posteromedial cortex with anatomical connectivity
揭示具有解剖连接性的后内侧皮质的功能网络和回路
- 批准号:
10054104 - 财政年份:2018
- 资助金额:
$ 37.53万 - 项目类别:
Anatomical connections subserving the default mode network
支持默认模式网络的解剖连接
- 批准号:
8889983 - 财政年份:2014
- 资助金额:
$ 37.53万 - 项目类别:
Anatomical connections subserving the default mode network
支持默认模式网络的解剖连接
- 批准号:
9088499 - 财政年份:2014
- 资助金额:
$ 37.53万 - 项目类别:
The role of cingulate cortex in reward-based decision making
扣带皮层在基于奖励的决策中的作用
- 批准号:
8215894 - 财政年份:2010
- 资助金额:
$ 37.53万 - 项目类别:
The role of cingulate cortex in reward-based decision making
扣带皮层在基于奖励的决策中的作用
- 批准号:
7807615 - 财政年份:2010
- 资助金额:
$ 37.53万 - 项目类别:
The role of cingulate cortex in reward-based decision making
扣带皮层在基于奖励的决策中的作用
- 批准号:
8033161 - 财政年份:2010
- 资助金额:
$ 37.53万 - 项目类别:
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