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Revealing functional networks and circuits of the posteromedial cortex withanatomical connectivity

揭示后内侧皮质的功能网络和回路与解剖学连接

基本信息

批准号：
10875048
负责人：
Sarah Rachel Heilbronner
金额：
$ 37.53万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-05 至 2024-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10875048
关键词：
Anatomy Anxiety Area Arousal Attention Axon Biological Biology Brain Brain region Cells Cognitive Complex Corpus striatum structure Data Deep Brain Stimulation Diffusion Magnetic Resonance Imaging Disease Dorsal Etiology Fiber Goals Human Impaired cognition Individual Injections Intervention Knowledge Label Laboratories Link Macaca mulatta Major Depressive Disorder Maps Medial Mental Depression Mental disorders Methods Neurons Non-Invasive Detection Pathway interactions Pattern Population Projection Positioning Attribute Post-Traumatic Stress Disorders Predisposition Prefrontal Cortex Research Research Personnel Rest Rewards Role Schizophrenia Scientist Self Perception Social Anxiety Disorder Temporal Lobe Tracer Transcranial magnetic stimulation Ventral Striatum Work base cingulate cortex connectome diffusion weighted experimental study improved neural neuroimaging neuronal circuitry neuroregulation nonhuman primate patient population response white matter

项目摘要

Project Summary The posteromedial cortex is a brain region that is especially abnormal in many psychiatric diseases, including depression, schizophrenia, and anxiety. However, it has traditionally received little attention from neuroscientists, in part because we do not understand its underlying biology. We propose to remedy this problem by uncovering posteromedial cortical circuits using tract-tracing in nonhuman primates and diffusion- weighted magnetic resonance imaging in nonhuman primates and humans. This pipeline will allow us to create a segmentation of the posteromedial cortex according to its anatomical connectivity. First, we propose to tile the nonhuman primate posteromedial cortex with tract-tracer injections, which will allow us to analyze its connectivity with other, better-understood brain regions. We will use these data to segment the posteromedial cortex according to its anatomical connectivity. We expect that different segments will connect with distinct, well-defined networks within the brain. Next, we will collect diffusion-weighted neuroimaging data in nonhuman primates and humans. Although this method allows noninvasive detection of some connections, it is highly susceptible to errors. We will use the principles of white matter organization identified in the tract-tracing data to guide and debug these neuroimaging data. Because tract-tracing cannot be performed in humans, this pipeline offers a rare possibility to infer anatomical connectivity in the human brain. Finally, based on prior neuroimaging experiments, scientists have hypothesized that the posteromedial cortex may connect with a particularly large number of brain regions and networks. Thus, we would like to determine the extent of axonal collateralization in the neurons of this brain region. In other words, does a single posteromedial cortical neuron project to many other brain regions, or are the circuits largely separate? Together, we expect these projects will elucidate PMC anatomical connectivity in such a way that large-scale neuroimaging networks can be linked with specific neuronal circuits.

项目总结