The menopausal transition and healthy ageing and wellbeing

更年期过渡与健康老龄化和福祉

• 批准号: G1001357/1
• 负责人: Debbie Lawlor
• 金额: $ 193.99万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1001357%2F1
• 关键词: menopausal; transition; healthy; ageing; wellbeing

The menopause is a key period in a woman?s life. It marks the end of her reproduction and is often associated with changes in heart disease risk factors, bone density and how much muscle and fat mass she has. This time period is also one when women frequently change their role in the family and may change occupation or employment status. Research has shown that some women feel positive about the menopause, because it marks the end to concerns about contraception and increased freedom to pursue some of their own interests and occupations. Others feel negatively towards the menopause because it marks the loss of youth and the ability to reproduce and because of some of the adverse symptoms associated with it. Few studies have examined in detail how all of these changes interact with each other and how risk factors in earlier life and genetic factors impact on the changes that occur as women go through the menopause. We plan to study biological, medical, social and economic characteristics, as well as body image, sexual health and family relationships as women go through the menopause. We will also study how earlier reproductive health, lifestyles and genetic factors affect these changes. We will undertake this study in a group of 2800 women who will go through the menopausal transition over the next 5 years. We already have a lot of data on these women and this further study will enable us to fully understand how changes that occur as women go through the menopause affect their health and wellbeing. Thus, our research represents good value for money.

更年期是女性的关键时期。年代的生活。这标志着女性生殖的结束，通常与心脏病风险因素、骨密度以及肌肉和脂肪量的变化有关。这一时期也是妇女经常改变她们在家庭中的角色，可能改变职业或就业状况的时期。研究表明，一些女性对更年期持积极态度，因为这标志着对避孕的担忧结束，并增加了追求自己兴趣和职业的自由。另一些人对更年期持消极态度，因为它标志着青春和生育能力的丧失，以及与之相关的一些不良症状。很少有研究详细研究了所有这些变化是如何相互作用的，以及早期生活中的风险因素和遗传因素是如何影响女性更年期发生的变化的。我们计划研究女性更年期的生物学、医学、社会和经济特征，以及身体形象、性健康和家庭关系。我们还将研究早期生殖健康、生活方式和遗传因素如何影响这些变化。我们将在2800名妇女中进行这项研究她们将在未来5年内经历更年期的转变。我们已经有了很多关于这些女性的数据，这项进一步的研究将使我们能够充分了解女性在更年期发生的变化是如何影响她们的健康和幸福的。因此，我们的研究物有所值。