The public health importance of vitamin D: determining causal effects of intrauterine and lifetime exposure to vitamin D

维生素 D 对公共卫生的重要性：确定宫内和终生接触维生素 D 的因果影响

• 批准号: G0701603/1
• 负责人: Debbie Lawlor
• 金额: $ 173.12万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0701603%2F1
• 关键词: public; health; importance; vitamin; determining

This aim of this grant is to determine whether low levels of vitamin D during fetal development and in childhood increase the risk for high blood pressure, high cholesterol and high glucose and insulin (markers of diabetes) in early adulthood. Vitamin D is generated by exposure of the skin to sunlight. Recent public health campaigns to reduce skin exposure to sunlight have been successful in reducing the occurrence of skin cancer, but there is some concern that they have also caused low levels of vitamin D in many people. Pregnant women and children in particular are likely to have inadequate levels. Low levels of vitamin D could have detrimental effects. There is increasing evidence that individuals who have lower levels of vitamin D have higher risk factors for diabetes and heart disease, such as higher fasting blood sugar levels and higher cholesterol and blood pressure. We will examine the association of vitamin D (measured in blood samples taken from their mothers during pregnancy and themselves when aged 7-9 years) with measures of blood cholesterol, glucose and insulin and blood pressure in a large study of individuals who are now aged 17-18 years.

这笔赠款的目的是确定胎儿发育期间和儿童时期维生素D水平低是否会增加成年初期患高血压、高胆固醇、高血糖和高胰岛素(糖尿病的标志)的风险。维生素D是通过皮肤暴露在阳光下而产生的。最近旨在减少皮肤暴露在阳光下的公共卫生运动在减少皮肤癌的发生方面取得了成功，但也有一些人担心，这些运动也导致了许多人体内维生素D的水平较低。孕妇，特别是儿童，很可能有不足的水平。低水平的维生素D可能会产生有害的影响。越来越多的证据表明，维生素D水平较低的人患糖尿病和心脏病的风险因素较高，例如空腹血糖水平较高，胆固醇和血压较高。我们将在一项针对17-18岁个体的大型研究中，研究维生素D(从怀孕期间的母亲和7-9岁时的自己身上采集的血液样本)与血液中胆固醇、葡萄糖、胰岛素和血压的相关性。