Does nitrite reduce ischaemia-reperfusion injury in patients with acute ST segment elevation myocardial infarction?

亚硝酸盐能否减轻急性ST段抬高型心肌梗死患者的缺血再灌注损伤？

• 批准号: G1001340/1
• 负责人: Michael Frenneaux
• 金额: $ 157.25万
• 依托单位: University of Aberdeen
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1001340%2F1
• 关键词: Does; nitrite; reduce; ischaemia; reperfusion

Heart attacks are common and are due to a blockage of one of the arteries that supply the heart with blood. The associated lack of oxygen supply causes death of the heart muscle supplied by this artery. Prompt opening of the blocked artery (eg by inflation of a balloon in the artery) limits the extent of this damage. However, the restoration of blood flow itself causes a degree of damage to the heart muscle. In this study we plan to investigate whether a drug called sodium nitrite given to patients suffering from heart attacks immediately before opening the blocked artery will reduce the damage to the heart muscle. This is important because when a large amount of heart muscle is damaged the patient is at risk of developing heart failure a condition associated with breathlessness and a poor survival.

心脏病发作很常见，是由于为心脏供血的动脉之一阻塞所致。相关的氧气供应不足会导致由该动脉供应的心肌死亡。迅速打开阻塞的动脉（例如通过动脉中的气球充气）可以限制这种损害的程度。然而，血流的恢复本身会对心肌造成一定程度的损伤。在这项研究中，我们计划调查心脏病发作患者在打开阻塞动脉之前服用一种名为亚硝酸钠的药物是否会减少对心肌的损伤。这很重要，因为当大量心肌受损时，患者有发生心力衰竭的风险，心力衰竭是一种与呼吸困难和生存率低相关的疾病。