Omega-1, a novel immunomodulator with potential to prevent Type 1 diabetes?

Omega-1，一种具有预防 1 型糖尿病潜力的新型免疫调节剂？

• 批准号: G1001737/1
• 负责人: Anne Cooke
• 金额: $ 56.74万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1001737%2F1
• 关键词: Omega; novel; immunomodulator; potential; prevent

Type 1 diabetes is an autoimmune disease which is increasing dramaticallyin incidence in the UK. The reasons behind this increase are unknown butone explanation is that a reduced exposure to infectious agents may beresponsible.We have previously shown using a mouse model of type 1diabetes that extracts of a parasite are able to inhibit development ofdiabetes in this mouse strain. It is not necessary to have a liveinfection to achieve diabetes prevention. Our studies furthermore showthat prevention is achieved by increasing regulation of the immuneresponse. We have preliminary data showing that a purified product of theparasite is able to induce a population of cells involved in immuneregulation. We propose to see whether this product can inhibit diabetes inour mice, whether it can also induce human regulatory cells and dissecthow a single molecule can do this. The importance of this work is that itmay lead to the development of a novel biomodulator that can be used toprevent diabetes onset in humans.

1型糖尿病是一种自身免疫性疾病，在英国发病率急剧上升。这种增加背后的原因尚不清楚，但一种解释是，接触感染性物质的减少可能是可能的。我们之前已经使用1型糖尿病的小鼠模型显示，寄生虫的提取物能够抑制这种小鼠品系的糖尿病发展。预防糖尿病并不一定要有活体感染。我们的研究进一步表明，预防是通过加强对免疫反应的调节来实现的。我们有初步数据表明，寄生虫的纯化产物能够诱导参与免疫调节的细胞群。我们打算看看这种产品是否可以抑制我们小鼠的糖尿病，它是否也可以诱导人类调节细胞，并剖析单个分子是如何做到这一点的。这项工作的重要性在于，它可能导致一种新的生物调节剂的开发，这种生物调节剂可以用来预防人类糖尿病的发生。