The role of dendritic cells in Salmonella typhimurium mediated diabetes prevention in NOD mice

树突状细胞在鼠伤寒沙门氏菌介导的 NOD 小鼠糖尿病预防中的作用

• 批准号: G0601174/1
• 负责人: Anne Cooke
• 金额: $ 61.23万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0601174%2F1
• 关键词: role; dendritic; cells; Salmonella; typhimurium

In Type 1 diabetes the immune system of an individual selectively destroys the cells in the body that secrete insulin, a hormone which is essential for maintaining glucose levels in the body. Although the development of this disease is governed by genetic factors it is clear that environmental factors additionally play a big role in determining whether Type 1 diabetes actually develops in a genetically prone individual. Among the environmental factors that might impact on diabetes development is infection. We, and others, have shown that some worm or bacterial infections actually prevent diabetes onset in a mouse model of Type 1 diabetes. By identifying the mechanisms by which infections prevent diabetes onset in this model this may lead to the development of novel therapies to prevent this autoimmune disease developing in humans.

在 1 型糖尿病中，个体的免疫系统选择性地破坏体内分泌胰岛素的细胞，胰岛素是维持体内葡萄糖水平所必需的激素。尽管这种疾病的发展受到遗传因素的控制，但很明显，环境因素在确定遗传倾向个体是否真正患上 1 型糖尿病方面也发挥着重要作用。可能影响糖尿病发展的环境因素之一是感染。我们和其他人已经证明，在 1 型糖尿病小鼠模型中，某些蠕虫或细菌感染实际上可以预防糖尿病的发生。通过在该模型中确定感染预防糖尿病发作的机制，可能会导致开发新的疗法来预防这种自身免疫性疾病在人类中的发展。