Using an animal model of type 1 diabetes to identify biomarkers of pre-symptomatic disease and treatment efficacy

使用 1 型糖尿病动物模型来识别症状前疾病的生物标志物和治疗效果

• 批准号: G0801841/1
• 负责人: Anne Cooke
• 金额: $ 59.01万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0801841%2F1
• 关键词: Using; animal; model; type; diabetes

In type 1 diabetes the immune system of an individual selectively destroys the cells in the body that secrete insulin, a hormone which is essential for maintaining glucose levels in the body. This autoimmune process can be going on for several years before sufficient insulin producing cells have been killed to make the person clinically ill. If you could detect those people who were suffering from such an autoimmune condition before they became clinically ill it would be possible to intervene therapeutically to prevent further loss of these very important cells. Such an early intervention would mean that there would be no need to have daily insulin injections and would prevent the development of diabetic complications. Therefore if biomarkers could be detected in blood samples this would represent a significant advance towards a better treatment for type 1 diabetes.

在1型糖尿病中，个体的免疫系统选择性地破坏体内分泌胰岛素的细胞，胰岛素是维持体内葡萄糖水平所必需的激素。这种自身免疫过程可能会持续数年，直到足够多的胰岛素产生细胞被杀死，使患者出现临床疾病。如果你能检测到那些在临床患病之前就患有这种自身免疫疾病的人，就有可能进行治疗干预，以防止这些非常重要的细胞进一步丧失。这样的早期干预将意味着不需要每天注射胰岛素，并将防止糖尿病并发症的发展。因此，如果可以在血液样本中检测到生物标记物，这将代表着朝着更好地治疗1型糖尿病的方向迈进了一大步。