A STUDY OF WOUND HEALING AND WOUND INFECTION

伤口愈合和伤口感染的研究

• 批准号: 3106060
• 负责人: THOMAS K. HUNT
• 金额: $ 43.11万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-01-01 至 1986-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3106060
• 关键词: trauma; wound healing; wound infection

We are searching for the "control points" of the healing and scarring process with the object of enhancing retarded repair in acutely injured patients, and, more importantly, to prevent excessive scarring and subsequent disability due to trauma, arthritis, arteriosclerosis, and other diseases of pathologic deposition of connective tissue. We have isolated several control points: 1) between coagulation, and angiogenesis and inflammation, 2) between macrophages and angiogenesis and fibroplasia, 3) between local lactoacidosis and collagen synthesis, and 4) between the circulation and the oxygen supply. Means of enhancing the chemical messages as well as blocking them are also being investigated. Immune contributions to normal repair are being studied in this regard since immune-stimulated cells also seem to excite scar formation. The inflammatory cells, the new vessels, and fiber-producing cells together create a specific environment, and we are investigating how this environment enhances signal reception of response. The inflammatory process, so important in inducing repair, is also responsible for resistance to infection, and the same environment which seems to support the healing response has properties which seem to reduce resistance to infection. Fortunately, our work shows that it is possible to create environmental conditions which enhance resistance to infection and still support the healing process.

我们正在寻找愈合和结疤过程的“控制点” 目的是增强急性损伤患者的延迟修复，以及， 更重要的是，为了防止过度疤痕和随后的残疾， 创伤、关节炎、动脉硬化和其他病理沉积疾病 结缔组织 我们已经分离出几个控制点：1）在凝固之间， 血管生成和炎症，2）巨噬细胞和血管生成之间， 纤维增生，3）局部乳酸中毒和胶原合成之间，和4） 在循环和氧气供应之间。 加强化学品的手段 消息以及阻止它们也正在调查中。 免疫 在这方面，正在研究对正常修复的贡献， 免疫刺激的细胞似乎也刺激疤痕形成。 炎症细胞、新生血管和纤维生成细胞 创造一个特定的环境，我们正在研究这个环境是如何 增强响应的信号接收。 炎症过程在诱导修复中非常重要， 抵抗感染的能力，同样的环境似乎也支持了 愈合反应具有似乎降低对感染的抵抗力的特性。 幸运的是，我们的工作表明， 增强对感染的抵抗力并仍然支持愈合的条件 过程