'Development and evaluation of biomarkers of infant nutrition, growth and body composition'

“婴儿营养、生长和身体成分生物标志物的开发和评估”

• 批准号: G1001995/1
• 负责人: Philippa Prentice
• 金额: $ 24.6万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1001995%2F1
• 关键词: Development; evaluation; biomarkers; infant; nutrition

We know that not only the conditions babies experience in the womb (in-utero) but also their nutrition in early life affects their growth and influences later childhood and adult weight gain. We aim to look for early markers of different babies‘ growth and body composition, reflecting in-utero exposures and nutrition after birth. Our project aims to identify these markers in blood. We will use different methods to look for these markers, including standard hormonal assay techniques, and newer methods looking at metabolic pathways.The project will use data from babies in the Cambridge Baby Growth Study cohort, (2001-2008). These babies have had several growth measurements taken, including weight, height and skinfold thicknesses, up until 2 years of age. Many of them have had blood taken, which we can use and match to different growth patterns. We will also aim to recruit new babies, focussing on those born to mothers with Diabetes. Understanding the markers of babies‘ growth will have great scientific and public implications, focussing on improving the health outcomes for the population. It will identify and predict how babies grow, risks for later obesity and the possibility of adapting early nutrition and feeding patterns in those at high risk.

我们知道，不仅婴儿在子宫内经历的状况，而且他们早期生活中的营养也会影响他们的成长，并影响童年后期和成年后的体重增加。我们的目标是寻找不同婴儿生长和身体组成的早期标志，反映出生后的子宫内暴露和营养。我们的项目旨在识别血液中的这些标记物。我们将使用不同的方法来寻找这些标记，包括标准的激素测定技术，以及寻找代谢途径的新方法。该项目将使用剑桥婴儿成长研究队列（2001-2008）中的婴儿数据。这些婴儿在两岁之前都进行了几项生长测量，包括体重、身高和皮褶厚度。他们中的许多人都取了血，我们可以用它来匹配不同的生长模式。我们还将致力于招募新生儿，重点是那些患有糖尿病的母亲所生的婴儿。了解婴儿生长的标志将具有重大的科学和公共意义，重点是改善人口的健康状况。它将识别和预测婴儿的生长方式、后期肥胖的风险以及高危人群适应早期营养和喂养模式的可能性。