权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Control of neuronal networks and cognitive behaviour by deep brain, transcranial and optogenetic stimulation

通过深部脑、经颅和光遗传学刺激控制神经网络和认知行为

基本信息

批准号：
G1002064/1
负责人：
Matt Jones
金额：
$ 202.38万
依托单位：
University of Bristol
依托单位国家：
英国
项目类别：
Fellowship
财政年份：
2011
资助国家：
英国
起止时间：
2011 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=G1002064%2F1
关键词：
Control neuronal networks cognitive behaviour

项目摘要

Your brain is constantly doing sums, weighing-up past experience and the current situation in order to decide how best to behave. Unfortunately, patients with brain diseases like schizophrenia have trouble coping with these decisions that most of us take for granted; electrical activity in different parts of their brains becomes subtly uncoordinated, making it difficult to see the wood for the trees. This project will use stimulation techniques designed to control the brain‘s electrical signalling (very carefully - you wouldn‘t notice if it was done to you) to see if we can re-coordinate brain activity at important times, such as during decisions. Brain activity during sleep is also important, often mirroring previous events. This reflects the brain ‘sorting out‘ recent thoughts, preparing useful information for long term storage. A bad night‘s sleep is often followed by sluggish thoughts, and sleep is commonly impaired in brain disease. We will therefore also use brain stimulation during sleep to see if that can boost efficient decision-making. It is difficult to design drugs to treat impaired thought processes. Our research will develop new techniques that - potentially in combination with future drugs - can be used to treat thought disorders in schizophrenia and related diseases.

你的大脑一直在做计算，权衡过去的经验和当前的情况，以决定如何表现得最好。不幸的是，患有精神分裂症等脑部疾病的患者很难应对这些我们大多数人认为理所当然的决定；他们大脑不同部分的电活动变得微妙地不协调，使得他们很难只见树木不见树木。这个项目将使用刺激技术来控制大脑的电信号（非常小心——如果是对你做的，你不会注意到），看看我们是否能在重要时刻重新协调大脑活动，比如在做决定的时候。睡眠期间的大脑活动也很重要，通常反映出之前的事件。这反映了大脑正在“整理”最近的想法，为长期存储准备有用的信息。一夜不好的睡眠往往伴随着懒散的思想，而睡眠通常会因脑部疾病而受损。因此，我们也将在睡眠中使用大脑刺激，看看是否能提高决策效率。很难设计药物来治疗受损的思维过程。我们的研究将开发出新的技术，可能与未来的药物相结合，用于治疗精神分裂症和相关疾病的思维障碍。