Developmental trajectories of psychosis in population-based samples: interplay between early adversity and familial risk

基于人群的样本中精神病的发展轨迹：早期逆境与家庭风险之间的相互作用

• 批准号: G1002366/1
• 负责人: Helen Fisher
• 金额: $ 35.15万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1002366%2F1
• 关键词: Developmental; trajectories; psychosis; population; based

Mental health problems such as psychosis (e.g., schizophrenia) can be extremely disabling and result in massive costs for the individual, NHS services and society in general. Greater understanding of what factors are involved in development and persistence of such disorders would assist attempts to prevent and treat them. One of the major factors thought to cause psychosis is an individual‘s genetic make-up but environmental factors are also thought to play a role, possibly in combination with genes. Therefore, I propose to investigate whether individuals who have been exposed to potentially distressing experiences in childhood (severely beaten by or separated from their parents) and have a genetic risk (positive family history) are more likely to experience psychotic symptoms (such as hearing voices) over a long period of time and require treatment for psychosis during the life-course than individuals with only one or neither of these factors. To test this proposition I will analyse data from four different longitudinal studies: three general population birth cohorts in adolescence and adulthood and a 10-year follow-up of clinically diagnosed psychosis patients on whom information is available about their family and childhood history and experience of psychotic symptoms and mental health treatment at different time points.

心理健康问题，如精神病（例如，精神分裂症）可能是极其残疾的，并导致个人、NHS服务和整个社会的巨大成本。更好地了解哪些因素参与了这些疾病的发展和持续，将有助于预防和治疗这些疾病。人们认为导致精神病的主要因素之一是个体的遗传组成，但环境因素也被认为发挥了作用，可能与基因相结合。因此，我们建议，我建议调查那些在童年时期暴露于潜在的痛苦经历（被父母毒打或与父母分离）并具有遗传风险（阳性家族史）的人是否更有可能在很长一段时间内经历精神病症状（如幻听），并在生命过程中需要治疗精神病，而不是只有一个或没有这些因素的人。为了检验这一命题，我将分析四个不同的纵向研究的数据：三个一般人群出生队列在青春期和成年期和10年的随访临床诊断的精神病患者的信息是关于他们的家庭和童年的历史和经验的精神病症状和精神健康治疗在不同的时间点。