Interaction between genetic risk and childhood adversity in the development of psychosis and depression.

遗传风险与童年逆境在精神病和抑郁症发展中的相互作用。

• 批准号: G0802674/1
• 负责人: Helen Fisher
• 金额: $ 20.15万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0802674%2F1
• 关键词: Interaction; between; genetic; risk; childhood

Mental health problems such as depression and psychosis (e.g., schizophrenia) can be extremely disabling disorders and result in a massive cost for both the individual and NHS services. Greater understanding of what factors are involved in development and persistence of such disorders would assist attempts to prevent and treat them. One of the major factors thought to cause these disorders is an individual‘s genetic make-up but researchers have struggled to identify the exact genes involved in this process possibly because they have largely ignored the role of environmental factors. Therefore, I propose to investigate whether individuals who have a genetic risk (either positive family history or specific genetic variant) and have been exposed to potentially distressing experiences in childhood (severely beaten by or separated from their parents) are more likely to be diagnosed with depression and psychosis than individuals with only one or neither of these factors. To test this proposition I will analyse data from two different cross-sectional case-control studies: an ongoing study of psychosis patients and unaffected individuals from the same geographical area; and a completed study of depressed patients and general population controls that have provided information about their family and childhood history and given DNA samples.

心理健康问题，如抑郁症和精神病（例如，精神分裂症）可能是极其致残的疾病，并导致个人和NHS服务的巨大成本。更好地了解哪些因素参与了这些疾病的发展和持续，将有助于预防和治疗这些疾病。被认为导致这些疾病的主要因素之一是个体的遗传组成，但研究人员一直在努力确定参与这一过程的确切基因，这可能是因为他们在很大程度上忽略了环境因素的作用。因此，我建议调查那些有遗传风险（阳性家族史或特定遗传变异）的人，以及那些在童年时期经历过潜在痛苦经历（被父母毒打或与父母分离）的人，是否比只有一个或没有这些因素的人更有可能被诊断为抑郁症和精神病。为了验证这一命题，我将分析两个不同的横断面病例对照研究的数据：一个是正在进行的研究，研究对象是来自同一地理区域的精神病患者和未受影响的个体;另一个是已完成的研究，研究对象是抑郁症患者和一般人群对照，他们提供了有关家族和童年史的信息，并提供了DNA样本。