E-Risk Longitudinal Twin Study age-30 follow-up: a unique resource for studying mental health, adversity & prosperity over the first 3 decades of life

E-Risk 纵向双胞胎研究 30 岁随访：研究心理健康、逆境的独特资源

• 批准号: MR/X010791/1
• 负责人: Helen Fisher
• 金额: $ 297.43万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FX010791%2F1
• 关键词: Risk; Longitudinal; Twin; Study; age

CONTEXT: The twenties are an important developmental period in which individuals traditionally become fully independent of their parents, complete their education, enter the workforce/housing-market, and develop stable relationships. How individuals navigate this early adulthood period will determine their health, well-being, and economic prosperity in mid-life. Unfortunately, the twenties are also the peak age for mental health problems, which can derail these key developmental tasks. The triple shocks of Brexit, the COVID-19 pandemic, and the transition to a Net Zero future have resulted in major societal changes and economic instability - we do not know how this will affect the mental health and prospects of young adults nor what will influence whether they falter or prosper. Therefore, we propose to assess young adults at the end of their twenties to capture the factors that may influence these different outcomes so that researchers and practitioners can explore how best to support the most vulnerable young adults to thrive in these unprecedented times, and ultimately influence policy.AIMS: This infrastructure funding bid aims to collect new data from twin participants of the Environmental Risk (E-Risk) Longitudinal Twin Study when they are 30 years old. The three decades worth of comprehensive clinical-quality data, genetic and biological stress markers, and linked administrative records will then be made freely and widely accessible to the research community.METHOD: We will capitalise upon the E-Risk Longitudinal Twin Study, a cohort of 2232 twins born in England and Wales in 1994-1995 who have completed extensive home-visit assessments (including on mental health, social experiences, deprivation, educational attainment, and provided biological samples) at 5, 7, 10, 12 and 18 years of age (when 93% of the twins were seen). This cohort is unique as study members are spread among poor (n=900), comfortably-off (n=700), and wealthier (n=600) families, allowing researchers to compare the outcomes of these groups. For this project we propose to collect new data on the twins when they are 30 years old in 2024-2025. This will involve remote assessments by trained researchers over Zoom on mental health, adverse life experiences, human-capital-building behaviours, social and economic outcomes, and potential protective factors. We will capture their quality of life and expectations about the future and social mobility via a tool developed by young adults with lived experience of mental health issues. A nurse will visit participants at home to collect a blood sample, and we will link data to their health, welfare, education, crime, social media, and geographical records. This updated dataset will be made freely available and widely accessible to researchers across the UK and globally. We will publicise this resource through webinars, journal papers, and websites, and create training videos to support researchers to access and use this data. Additionally, our young-adult advisors will produce a priority list of questions for researchers to answer with the E-Risk dataset.BENEFITS: This project will provide a unique resource for researchers to conduct genetically informed investigations of how mental health problems, biological factors, social inequality and adversity in the first two decades of life shape variation in mental health, pace of aging, relationships/connectedness, trust, future expectations/aspirations, and prosperity in the third decade of life. Such research will provide important insights into which factors lead to young adults faltering or prospering in this period of social and economic turmoil. These insights are crucial to inform policy, practice, and societal responses to support young adults to thrive in these unprecedented times. Increasing the number of young adults who are mentally healthy and socially mobile in mid-life could ultimately boost the UK economy and reduce strain on the NHS.

背景：20多岁是一个重要的发展时期，在这个时期，个人传统上完全独立于父母，完成学业，进入劳动力市场/住房市场，发展稳定的关系。个人如何度过这段早期成年期将决定他们在中年时的健康、幸福和经济繁荣。不幸的是，20多岁也是心理健康问题的高峰期，这可能会破坏这些关键的发展任务。英国脱欧、COVID-19大流行和向净零未来过渡的三重冲击导致了重大的社会变革和经济不稳定——我们不知道这将如何影响年轻人的心理健康和前景，也不知道什么会影响他们是步履蹒跚还是繁荣。因此，我们建议对20多岁的年轻人进行评估，以捕捉可能影响这些不同结果的因素，以便研究人员和从业人员可以探索如何最好地支持最脆弱的年轻人在这个前所未有的时代茁壮成长，并最终影响政策。目的：这项基础设施资助招标旨在从环境风险（E-Risk）纵向双胞胎研究的双胞胎参与者那里收集30岁时的新数据。三十年来的综合临床质量数据、遗传和生物压力标记以及相关的行政记录将免费并广泛地提供给研究界。方法：我们将利用E-Risk纵向双胞胎研究，对1994-1995年出生在英格兰和威尔士的2232对双胞胎进行队列研究，这些双胞胎在5岁、7岁、10岁、12岁和18岁（93%的双胞胎被看到）时完成了广泛的家访评估（包括心理健康、社会经历、剥夺、教育程度，并提供了生物样本）。这个队列是独特的，因为研究成员分布在贫穷（n=900）、富裕（n=700）和富裕（n=600）家庭中，使研究人员能够比较这些群体的结果。在这个项目中，我们建议在2024-2025年这对双胞胎30岁时收集新的数据。这将涉及由训练有素的研究人员通过Zoom对心理健康、不良生活经历、人力资本建设行为、社会和经济结果以及潜在的保护因素进行远程评估。我们将通过一个由有心理健康问题生活经验的年轻人开发的工具，捕捉他们的生活质量、对未来和社会流动性的期望。一名护士将上门访问参与者，采集血样，我们将把数据与他们的健康、福利、教育、犯罪、社交媒体和地理记录联系起来。这个更新的数据集将免费提供给英国和全球的研究人员。我们将通过网络研讨会、期刊论文和网站来宣传这些资源，并创建培训视频来支持研究人员访问和使用这些数据。此外，我们的年轻成年顾问将为研究人员提供一个优先问题列表，让他们用E-Risk数据集回答。好处：该项目将为研究人员提供一个独特的资源，以开展遗传知情调查，研究生命前20年的心理健康问题、生物因素、社会不平等和逆境如何影响生命第三个十年的心理健康变化、衰老速度、关系/联系、信任、未来期望/愿望和繁荣。这样的研究将提供重要的见解，哪些因素导致年轻人在这个社会和经济动荡时期步履蹒跚或繁荣。这些见解对于为政策、实践和社会反应提供信息，以支持年轻人在这个前所未有的时代茁壮成长至关重要。增加中年时期心理健康、社会流动性强的年轻人的数量，最终可能会提振英国经济，并减轻英国国民健康保险制度（NHS）的压力。

项目成果

Problematic technology use and sleep quality in young adulthood: novel insights from a nationally representative twin study.

• DOI: 10.1093/sleep/zsad038
• 发表时间: 2023-06-13
• 期刊: Sleep
• 影响因子: 5.6

Cross-National and Cross-Generational Evidence That Educational Attainment May Slow the Pace of Aging in European-Descent Individuals.

跨国家和跨代证据表明，教育程度可能会减缓欧洲人后裔的衰老速度。

• DOI: 10.1093/geronb/gbad056
• 发表时间: 2023
• 期刊: The journals of gerontology. Series B, Psychological sciences and social sciences
• 作者: Sugden,Karen;Moffitt,TerrieE;Arpawong,ThalidaEm;Arseneault,Louise;Belsky,DanielW;Corcoran,DavidL;Crimmins,EileenM;Hannon,Eilis;Houts,Renate;Mill,JonathanS;Poulton,Richie;Ramrakha,Sandhya;Wertz,Jasmin;Williams,BenjaminS;C
• 通讯作者: C

Do polygenic indices capture "direct" effects on child externalizing behavior? Within-family analyses in two longitudinal birth cohorts.

多基因指数是否捕获了对儿童外化行为的“直接”影响？

• DOI: 10.1101/2023.05.31.23290802
• 发表时间: 2023
• 期刊: the preprint server for health sciences
• 作者: Tanksley PT

Do Children With Attention-Deficit/Hyperactivity Disorder Symptoms Become Socially Isolated? Longitudinal Within-Person Associations in a Nationally Representative Cohort.

• DOI: 10.1016/j.jaacop.2023.02.001
• 发表时间: 2023-06
• 期刊: JAACAP open
• 作者: Thompson, Katherine N;Agnew-Blais, Jessica C;Allegrini, Andrea G;Bryan, Bridget T;Danese, Andrea;Odgers, Candice L;Matthews, Timothy;Arseneault, Louise
• 通讯作者: Arseneault, Louise

The socioeconomic consequences of loneliness: Evidence from a nationally representative longitudinal study of young adults

孤独的社会经济后果：来自全国代表性年轻人纵向研究的证据

• DOI: 10.1016/j.socscimed.2024.116697
• 发表时间: 2024
• 期刊: Social Science & Medicine
• 影响因子: 5.4
• 作者: Bryan B