Detecting Biomarkers of Brain Health in Dementia

检测痴呆症患者大脑健康的生物标志物

• 批准号: nhmrc : 1136913
• 负责人: A/Pr Anna King
• 金额: $ 48.69万
• 依托单位: Antarctic Climate and Ecosystems CRC, University of Tasmania
• 依托单位国家: 澳大利亚
• 项目类别: Targeted Calls
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/detecting-biomarkers-brain-health-dementia/1318519
• 关键词: Detecting; Biomarkers; Brain; Health; Dementia

Nerve cells communicate with each other through nerve processes or neurites. The dysfunction of neurites results in the clinical symptoms of dementia such as cognitive decline. Currently we cannot directly monitor degeneration of neurites in the living brain and therefore it is difficult to determine whether therapeutic agents are protective. My goal is to develop a detection system in the blood that will allow us to monitor these changes during disease progression and therapeutic intervention.

神经细胞通过神经突起或神经突相互交流。神经突的功能障碍导致痴呆的临床症状，如认知能力下降。目前，我们不能直接监测活体大脑中神经突的变性，因此很难确定治疗剂是否具有保护作用。我的目标是开发一种血液检测系统，使我们能够在疾病进展和治疗干预期间监测这些变化。