The role of excitotoxicity in mediating distal axonal degneration in ALS

兴奋性毒性在介导 ALS 远端轴突变性中的作用

• 批准号: nhmrc : 1003931
• 负责人: A/Pr Anna King
• 金额: $ 26.2万
• 依托单位: Antarctic Climate and Ecosystems CRC, University of Tasmania
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-excitotoxicity-mediating-degneration-als/108984
• 关键词: role; excitotoxicity; mediating; distal; axonal

Amyotrophic lateral sclerosis (ALS), the major cause of motor neuron disease, is a devastating diseasse for which there is no cure. There have been significant advances in understanding the pathology of ALS yet we still don’t know what causes the dying back of spinal motor neurons. We have new evidence that suggests that ALS may, in part, be caused by excitotoxcity - or over stimulation - of neurons in the spinal cord. We will follow this lead using a range of cutting edge experimental models.

肌萎缩侧索硬化症（amyotrophiclateralsclerosis，ALS）是运动神经元疾病的主要病因，目前尚无治愈的方法。在了解ALS的病理学方面已经取得了重大进展，但我们仍然不知道是什么原因导致脊髓运动神经元死亡。我们有新的证据表明，ALS可能部分是由脊髓神经元的兴奋性毒性或过度刺激引起的。我们将使用一系列尖端的实验模型来跟踪这一线索。