Predicting drug response in schizophrenia: are clinical & cognitive tests a cost-effective alternative to neuroimaging?

预测精神分裂症的药物反应：临床

• 批准号: G1100574/1
• 负责人: Andrea Mechelli
• 金额: $ 26.15万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1100574%2F1
• 关键词: Predicting; drug; response; schizophrenia; clinical

Schizophrenia is a severely debilitating disorder affecting 1% of the population. It is characterized by a range of symptoms including false beliefs, false perceptions and disorganized thinking. Medication can reduce these symptoms, but the response varies from one individual to another, in an unpredictable way. As a result, finding the most useful treatment for a given person involves trying s series of different medications, which often takes a long time and prolongs patient suffering. The aim of this research is to find out whether it is possible to predict how well a given patient will respond to a particular medication, without having to go through a trial period of treatment. This will be achieved by measuring a number of things before treatment is given, and then assessing which of these measures best predicts how effective the treatment is. The researchers will carry out brain scans and acquire demographic, clinical and psychological information in a large group of patients who have not been treated before. The researchers expect that these measures can help predict how well a patient will respond to antipsychotic medication, and that some quite simple things that are easy to assess may be as useful as more complicated measures like brain scans. The research should help doctors choose the most suitable treatment for each patient they see.

精神分裂症是一种严重的衰弱性疾病，影响1%的人口。它的特点是一系列的症状，包括错误的信念，错误的看法和混乱的思维。药物可以减轻这些症状，但反应因个体而异，以不可预测的方式。因此，要为特定的人找到最有效的治疗方法，就需要尝试一系列不同的药物，这往往需要很长时间，而且会给病人带来痛苦。这项研究的目的是找出是否有可能预测一个给定的病人将如何对特定的药物反应，而不必经历一个试验期的治疗。这将通过在给予治疗之前测量一些事情来实现，然后评估这些措施中哪一个最能预测治疗的有效性。研究人员将对一大群以前没有接受过治疗的患者进行脑部扫描，并获取人口统计学、临床和心理信息。研究人员希望这些措施可以帮助预测患者对抗精神病药物的反应，并且一些很容易评估的非常简单的事情可能与大脑扫描等更复杂的措施一样有用。这项研究应该帮助医生为他们看到的每个病人选择最合适的治疗方法。