Detection of Cardiac Allograft Rejection by Peripheral Blood Gene Expression: A Novel Concept of Personalized Approach to Transplantation.

通过外周血基因表达检测心脏同种异体移植排斥：个性化移植方法的新概念。

• 批准号: nhmrc : 1051113
• 负责人: A/Pr Robert Weintraub
• 金额: $ 19.52万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/detection-cardiac-allograft-approach-transplantation/112200
• 关键词: Detection; Cardiac; Allograft; Rejection; Peripheral

Heart biopsy is required to detect rejection after heart transplantation. The cost of each biopsy is around $7,000 and at least 10 heart biopsies needed in the first post-transplant year alone. The biopsy is difficult for the patients and significant cost for the Australian healthcare system. Thus, it would be beneficial to identify rejection using a simple blood test. Such tool would help to reduce or eliminate the need for expensive heart biopsy and would reduce the cost by about 10 times.

为了检测心脏移植后的排斥反应，需要进行心脏活检。每次活组织检查的费用约为7000美元，仅在移植后的第一年就需要至少10次心脏活组织检查。活检对患者来说是困难的，对澳大利亚的医疗保健系统来说成本很高。因此，通过简单的血液测试来识别排斥反应是有益的。这种工具将有助于减少或消除对昂贵的心脏活检的需要，并将成本降低约10倍。