Genetic Basis of Valvular Heart Disease

瓣膜性心脏病的遗传基础

• 批准号: nhmrc : 1023318
• 负责人: A/Pr Robert Weintraub
• 金额: $ 29.92万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genetic-basis-valvular-heart-disease/110265
• 关键词: Genetic; Basis; Valvular; Heart; Disease

Valvular heart disease is a common cause of heart failure. Identification of the genetic causes of valvular heart disease has important implications in our understanding of these heart diseases, as well as translating these genetic discoveries into better diagnostic and prevention strategies in at-risk families. This research proposal seeks to perform a comprehensive clinical and genetic investigation of individuals and families with the two most common valvular heart diseases, mitral valve prolapse and congenital bicuspid aortic valve.

瓣膜性心脏病是导致心力衰竭的常见原因。确定瓣膜性心脏病的遗传原因对我们对这些心脏病的理解具有重要意义，并将这些遗传发现转化为高危家庭更好的诊断和预防策略。本研究计划旨在对患有两种最常见的心脏瓣膜疾病，二尖瓣脱垂和先天性二尖瓣主动脉瓣的个体和家族进行全面的临床和遗传调查。