Establishment of a Resource for Long-Term Study of Hepatitis C Virus Infection in the UK - HCV Research UK

在英国建立丙型肝炎病毒感染长期研究资源 - HCV Research UK

• 批准号: MC_EX_G1000717
• 负责人: John McLauchlan
• 金额: $ 126.4万
• 依托单位: MRC University of Glasgow Centre for Virus Research
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_EX_G1000717
• 关键词: Establishment; Resource; Long; Term; Study

Clinical problems associated with chronic infection by hepatitis C virus (HCV) will continueto increase in the UK for the foreseeable future. While there has been considerableprogress with understanding the biology of the virus and improvements in healthcareprovision, many issues relevant to the characteristics of HCV infection in the UK remainunresolved, such as the factors that contribute to development of serious liver diseaseand failure to respond to treatment. To address these issues, this proposal aims to createthe infrastructure that will allow recruitment of a national cohort of at least 10,000patients. Assembling a cohort of this size is necessary to generate a representative butsufficiently diverse collection of patient characteristics and clinical samples to explore indetail the determinants that may contribute to HCV pathogenesis and response totreatment. The key components of the national resource that will be created are a clinicalresearch database for retaining details of patient characteristics, a biobank of clinicalsamples, which will form a UK repository, and a sequence and bioinformatics database tohold viral and host genetic information. The infrastructure will be supported by and buildupon existing knowledge and expertise at national agencies (Health Protection Agencyand Health Protection Scotland), the Gastroenterology and Liver Disease BiomedicalResearch Unit at Nottingham and the MRC Virology Unit in Glasgow. Patients will berecruited from clinical centres across most of the UK who provide care for HCV-infectedpatients. To provide proof of principle for the utility of clinical research and sequencedatabases combined with the availability of a biobank of clinical samples, a limited seriesof research projects will be performed. The projects will focus on examining whetherthere is a correlation between patient genetic markers and treatment outcome. Inaddition, the viral sequences of a large number of isolates for HCV genotypes 1 and 3 indifferent ethnic groups will be determined. These studies will provide the foundation forthe information that will be deposited in the sequence and bioinformatics database. Theavailability of such a well-structured resource is highly likely to stimulate greater clinicaland fundamental research into HCV infection in the UK and will also form the basis forlongitudinal studies into the natural history of chronic infection in a large cohort ofpatients.

在可预见的未来，英国与丙型肝炎病毒（HCV）慢性感染相关的临床问题将继续增加。虽然在了解病毒生物学和改善医疗保健方面取得了可喜的进展，但英国与HCV感染特征相关的许多问题尚未解决，例如导致严重肝病发展和治疗无效的因素。为了解决这些问题，该提案旨在加强基础设施，以允许招募至少10，000名患者的全国队列。收集一个具有代表性但足够多样化的患者特征和临床样本，以详细探讨可能导致HCV发病机制和治疗反应的决定因素，有必要建立一个这样规模的队列。将建立的国家资源的关键组成部分是一个临床研究数据库，用于保留患者特征的详细信息，一个临床样本生物库，将形成一个英国储存库，以及一个序列和生物信息学数据库，用于保存病毒和宿主遗传信息。该基础设施将得到国家机构（健康保护局和苏格兰健康保护局）、诺丁汉的胃肠病学和肝病生物医学研究单位以及格拉斯哥的MRC病毒学单位现有知识和专业知识的支持和建设。患者将从英国大部分为HCV感染患者提供护理的临床中心招募。为了提供临床研究和序列数据库的实用性的原理证明，结合临床样本生物库的可用性，将进行有限的一系列研究项目。这些项目将集中研究患者遗传标记和治疗结果之间是否存在相关性。此外，还将测定大量HCV基因型1和3不同种族人群分离株的病毒序列。这些研究将为序列和生物信息学数据库中存储的信息提供基础。这样一个结构良好的资源的可用性是非常有可能刺激更大的临床和基础研究丙型肝炎病毒感染在英国，也将形成纵向研究的基础，在一个大的队列的慢性感染的自然史的患者。