Part of the Cambridge Initiative in metabolic science to enhance the Epidemiology Unit’s existing research programmes.

这是剑桥代谢科学倡议的一部分，旨在加强流行病学部门现有的研究项目。

• 批准号: MC_EX_MR/L100002/1
• 负责人: Nicholas Wareham
• 金额: $ 318.55万
• 依托单位: MRC Epidemiology Unit
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_EX_MR%2FL100002%2F1
• 关键词: Part; Cambridge; Initiative; metabolic; science

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前GtR中并没有所有资助研究的摘要。这通常是因为在提交提案时不需要摘要，但也可能是因为摘要中包含个人详细信息等敏感信息。

项目成果

DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases.

• DOI: 10.1186/s13059-016-1119-5
• 发表时间: 2016-12-12
• 期刊: Genome biology
• 影响因子: 12.3
• 作者: Ligthart S;Marzi C;Aslibekyan S;Mendelson MM;Conneely KN;Tanaka T;Colicino E;Waite LL;Joehanes R;Guan W;Brody JA;Elks C;Marioni R;Jhun MA;Agha G;Bressler J;Ward-Caviness CK;Chen BH;Huan T;Bakulski K;Salfati EL;WHI-EMPC Investigators;Fiorito G;CHARGE epigenetics of Coronary Heart Disease;Wahl S;Schramm K;Sha J;Hernandez DG;Just AC;Smith JA;Sotoodehnia N;Pilling LC;Pankow JS;Tsao PS;Liu C;Zhao W;Guarrera S;Michopoulos VJ;Smith AK;Peters MJ;Melzer D;Vokonas P;Fornage M;Prokisch H;Bis JC;Chu AY;Herder C;Grallert H;Yao C;Shah S;McRae AF;Lin H;Horvath S;Fallin D;Hofman A;Wareham NJ;Wiggins KL;Feinberg AP;Starr JM;Visscher PM;Murabito JM;Kardia SL;Absher DM;Binder EB;Singleton AB;Bandinelli S;Peters A;Waldenberger M;Matullo G;Schwartz JD;Demerath EW;Uitterlinden AG;van Meurs JB;Franco OH;Chen YI;Levy D;Turner ST;Deary IJ;Ressler KJ;Dupuis J;Ferrucci L;Ong KK;Assimes TL;Boerwinkle E;Koenig W;Arnett DK;Baccarelli AA;Benjamin EJ;Dehghan A
• 通讯作者: Dehghan A

Associations between body mass index-related genetic variants and adult body composition: The Fenland cohort study.

• DOI: 10.1038/ijo.2017.11
• 发表时间: 2017-04
• 期刊: International journal of obesity (2005)
• 作者: Clifton EA;Day FR;De Lucia Rolfe E;Forouhi NG;Brage S;Griffin SJ;Wareham NJ;Ong KK
• 通讯作者: Ong KK

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

基因组分析确定了数百种与初潮年龄相关的变异，并支持青春期时机在癌症风险中的作用

• DOI: 10.17863/cam.9404
• 发表时间: 2017
• 作者: Day, FR

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis

支链氨基酸代谢受损的遗传倾向和 2 型糖尿病的风险：孟德尔随机分析

• DOI: 10.17863/cam.7150
• 发表时间: 2016
• 作者: Lotta L

Interaction between genes and macronutrient intake on the risk of developing type 2 diabetes: systematic review and findings from EPIC-InterAct

基因和宏量营养素摄入之间的相互作用对罹患 2 型糖尿病的风险的影响：EPIC-InterAct 的系统回顾和发现

• DOI: 10.17863/cam.9582
• 发表时间: 2017
• 作者: Li X