High Throughput Science - Investigating the genetic determinants of healthy ageing: the MRC EPIC-Norfolk study

高通量科学 - 调查健康老龄化的遗传决定因素:MRC EPIC-诺福克研究

基本信息

  • 批准号:
    MC_PC_13048
  • 负责人:
  • 金额:
    $ 170.87万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Intramural
  • 财政年份:
    2013
  • 资助国家:
    英国
  • 起止时间:
    2013 至 无数据
  • 项目状态:
    已结题

项目摘要

The EPIC-Norfolk study is a prospective population-based cohort study which recruited 25,000 men and women aged 40-79 years at baseline between 1993 and 1997 from 35 participating general practices in Norfolk. Individuals provided information about lifestyle behavioural factors including diet and activity and attended for a baseline health check including the provision of blood samples for concurrent and future analysis. They provided consent to future linkage to medical record information and a wide range of follow-up studies for different disease endpoints (including incident T2DM) have subsequently been undertaken (see www.srl.cam.ac.uk/epic). From 1998, participants were re-invited to attend a second health check at which baseline measures were repeated and additional measurements were added including ultrasound measurement of heel bone density and impedance assessment of total body fat. Between 2006 and 2011 a third health check was completed in which the focus of attention was on functional capacity with assessment of cognition, visual function and physical performance. A fourth health check is currently underway in which assessments of functional capacity are being repeated (grip strength, balance test, gait speed and chair stand) together with objective measurement of body composition including lean muscle mass by DEXA and physical activity and sedentary behaviour by accelerometry (Actigraph).DNA has been extracted from all EPIC participants and stored blood has been analysed for an extensive range of classical and novel biomarkers including measures of inflammation, sex hormones and nutrition (e.g. plasma vitamins C, and D, and carotenoids). A genomewide association study was originally conducted with EPIC-Norfolk in a case-cohort study design for obesity (N= 3552) including a random sub-cohort of 2417 individuals and 1135 obese people. The GWAS coverage is now being expanded to the entire EPIC Norfolk cohort funded by MRC.
EPIC-诺福克研究是一项基于人群的前瞻性队列研究,在1993至1997年间,从诺福克参与的35家普通诊所中招募了25,000名年龄在40-79岁之间的男性和女性。个人提供了关于包括饮食和活动在内的生活方式行为因素的信息,并参加了基线健康检查,包括提供供同时和未来分析的血液样本。他们同意今后与病历信息建立联系,随后对不同的疾病终点(包括T2 DM事件)进行了广泛的后续研究(见www.srl.cam.ac.uk/epic)。从1998年开始,参与者再次被邀请参加第二次健康检查,在检查中重复基线测量,并增加额外的测量,包括超声测量脚跟骨密度和全身脂肪的阻抗评估。2006至2011年间,完成了第三次健康检查,重点是功能能力,评估认知、视觉功能和身体表现。目前正在进行第四次健康检查,重复进行功能能力评估(握力、平衡测试、步速和椅子站立),同时客观测量身体成分,包括用DEXA测量瘦肌肉质量和用加速度计(Actigraph)测量身体活动和久坐行为。已从所有EPIC参与者身上提取DNA,并对储存的血液进行了广泛的分析,以检测一系列经典和新的生物标记物,包括炎症、性激素和营养指标(例如,血浆维生素C、维生素D和类胡萝卜素)。一项全基因组的关联研究最初是与EPIC-诺福克在肥胖症(N=3552)的病例队列研究设计中进行的,包括2417名个体和1135名肥胖者的随机子队列。GWA的覆盖范围现在正在扩大到由MRC资助的整个史诗诺福克队列。

项目成果

期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Prediction of acute myeloid leukaemia risk in healthy individuals
健康个体急性髓性白血病风险的预测
  • DOI:
    10.17863/cam.30393
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Abelson S
  • 通讯作者:
    Abelson S
Genome-wide analysis identifies 12 loci influencing human reproductive behavior.
  • DOI:
    10.1038/ng.3698
  • 发表时间:
    2016-12
  • 期刊:
  • 影响因子:
    30.8
  • 作者:
    Barban N;Jansen R;de Vlaming R;Vaez A;Mandemakers JJ;Tropf FC;Shen X;Wilson JF;Chasman DI;Nolte IM;Tragante V;van der Laan SW;Perry JR;Kong A;BIOS Consortium;Ahluwalia TS;Albrecht E;Yerges-Armstrong L;Atzmon G;Auro K;Ayers K;Bakshi A;Ben-Avraham D;Berger K;Bergman A;Bertram L;Bielak LF;Bjornsdottir G;Bonder MJ;Broer L;Bui M;Barbieri C;Cavadino A;Chavarro JE;Turman C;Concas MP;Cordell HJ;Davies G;Eibich P;Eriksson N;Esko T;Eriksson J;Falahi F;Felix JF;Fontana MA;Franke L;Gandin I;Gaskins AJ;Gieger C;Gunderson EP;Guo X;Hayward C;He C;Hofer E;Huang H;Joshi PK;Kanoni S;Karlsson R;Kiechl S;Kifley A;Kluttig A;Kraft P;Lagou V;Lecoeur C;Lahti J;Li-Gao R;Lind PA;Liu T;Makalic E;Mamasoula C;Matteson L;Mbarek H;McArdle PF;McMahon G;Meddens SF;Mihailov E;Miller M;Missmer SA;Monnereau C;van der Most PJ;Myhre R;Nalls MA;Nutile T;Kalafati IP;Porcu E;Prokopenko I;Rajan KB;Rich-Edwards J;Rietveld CA;Robino A;Rose LM;Rueedi R;Ryan KA;Saba Y;Schmidt D;Smith JA;Stolk L;Streeten E;Tönjes A;Thorleifsson G;Ulivi S;Wedenoja J;Wellmann J;Willeit P;Yao J;Yengo L;Zhao JH;Zhao W;Zhernakova DV;Amin N;Andrews H;Balkau B;Barzilai N;Bergmann S;Biino G;Bisgaard H;Bønnelykke K;Boomsma DI;Buring JE;Campbell H;Cappellani S;Ciullo M;Cox SR;Cucca F;Toniolo D;Davey-Smith G;Deary IJ;Dedoussis G;Deloukas P;van Duijn CM;de Geus EJ;Eriksson JG;Evans DA;Faul JD;Sala CF;Froguel P;Gasparini P;Girotto G;Grabe HJ;Greiser KH;Groenen PJ;de Haan HG;Haerting J;Harris TB;Heath AC;Heikkilä K;Hofman A;Homuth G;Holliday EG;Hopper J;Hyppönen E;Jacobsson B;Jaddoe VW;Johannesson M;Jugessur A;Kähönen M;Kajantie E;Kardia SL;Keavney B;Kolcic I;Koponen P;Kovacs P;Kronenberg F;Kutalik Z;La Bianca M;Lachance G;Iacono WG;Lai S;Lehtimäki T;Liewald DC;LifeLines Cohort Study;Lindgren CM;Liu Y;Luben R;Lucht M;Luoto R;Magnus P;Magnusson PK;Martin NG;McGue M;McQuillan R;Medland SE;Meisinger C;Mellström D;Metspalu A;Traglia M;Milani L;Mitchell P;Montgomery GW;Mook-Kanamori D;de Mutsert R;Nohr EA;Ohlsson C;Olsen J;Ong KK;Paternoster L;Pattie A;Penninx BW;Perola M;Peyser PA;Pirastu M;Polasek O;Power C;Kaprio J;Raffel LJ;Räikkönen K;Raitakari O;Ridker PM;Ring SM;Roll K;Rudan I;Ruggiero D;Rujescu D;Salomaa V;Schlessinger D;Schmidt H;Schmidt R;Schupf N;Smit J;Sorice R;Spector TD;Starr JM;Stöckl D;Strauch K;Stumvoll M;Swertz MA;Thorsteinsdottir U;Thurik AR;Timpson NJ;Tung JY;Uitterlinden AG;Vaccargiu S;Viikari J;Vitart V;Völzke H;Vollenweider P;Vuckovic D;Waage J;Wagner GG;Wang JJ;Wareham NJ;Weir DR;Willemsen G;Willeit J;Wright AF;Zondervan KT;Stefansson K;Krueger RF;Lee JJ;Benjamin DJ;Cesarini D;Koellinger PD;den Hoed M;Snieder H;Mills MC
  • 通讯作者:
    Mills MC
Prediction of acute myeloid leukaemia risk in healthy individuals.
在健康个体中预测急性髓样白血病的风险。
  • DOI:
    10.1038/s41586-018-0317-6
  • 发表时间:
    2018-07
  • 期刊:
  • 影响因子:
    64.8
  • 作者:
    Abelson S;Collord G;Ng SWK;Weissbrod O;Mendelson Cohen N;Niemeyer E;Barda N;Zuzarte PC;Heisler L;Sundaravadanam Y;Luben R;Hayat S;Wang TT;Zhao Z;Cirlan I;Pugh TJ;Soave D;Ng K;Latimer C;Hardy C;Raine K;Jones D;Hoult D;Britten A;McPherson JD;Johansson M;Mbabaali F;Eagles J;Miller JK;Pasternack D;Timms L;Krzyzanowski P;Awadalla P;Costa R;Segal E;Bratman SV;Beer P;Behjati S;Martincorena I;Wang JCY;Bowles KM;Quirós JR;Karakatsani A;La Vecchia C;Trichopoulou A;Salamanca-Fernández E;Huerta JM;Barricarte A;Travis RC;Tumino R;Masala G;Boeing H;Panico S;Kaaks R;Krämer A;Sieri S;Riboli E;Vineis P;Foll M;McKay J;Polidoro S;Sala N;Khaw KT;Vermeulen R;Campbell PJ;Papaemmanuil E;Minden MD;Tanay A;Balicer RD;Wareham NJ;Gerstung M;Dick JE;Brennan P;Vassiliou GS;Shlush LI
  • 通讯作者:
    Shlush LI
Fatigue is associated with excess mortality in the general population: results from the EPIC-Norfolk study.
  • DOI:
    10.1186/s12916-016-0662-y
  • 发表时间:
    2016-08-20
  • 期刊:
  • 影响因子:
    9.3
  • 作者:
    Basu N;Yang X;Luben RN;Whibley D;Macfarlane GJ;Wareham NJ;Khaw KT;Myint PK
  • 通讯作者:
    Myint PK
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Nicholas Wareham其他文献

Lipoprotein(a) improves cardiovascular risk prediction based on the ACC/AHA and score algorithms in intermediate risk patients; the EPIC-Norfolk prospective population study
  • DOI:
    10.1016/j.atherosclerosis.2017.06.111
  • 发表时间:
    2017-08-01
  • 期刊:
  • 影响因子:
  • 作者:
    Rutger Verbeek;Manjinder Sandhu;G. Kees Hovingh;Barbara Sjouke;Nicholas Wareham;Aeilko Zwinderman;John Kastelein;Kay-Tee Khaw;Sotirios Tsimikas;S. Matthijs Boekholdt
  • 通讯作者:
    S. Matthijs Boekholdt
Multilocus gene score or a metabolic risk score for severe hypertriglyceridemia and CVD risk prediction
  • DOI:
    10.1016/j.atherosclerosis.2017.06.271
  • 发表时间:
    2017-08-01
  • 期刊:
  • 影响因子:
  • 作者:
    Rutger Verbeek;Federico Oldoni;S. Matthijs Boekholdt;Aeilko Zwinderman;Erik Stroes;Jan Albert Kuijvenhoven;Nicholas Wareham;Kay Tee Khaw;G. Kees Hovingh;Geesje Dallinga-Thie
  • 通讯作者:
    Geesje Dallinga-Thie
Remnant cholesterol and systemic inflammation: Unraveling their association with cardiovascular disease
  • DOI:
    10.1016/j.atherosclerosis.2024.118321
  • 发表时间:
    2024-08-01
  • 期刊:
  • 影响因子:
  • 作者:
    Jordan Kraaijenhof;Marije Kerkvliet;Nick Nurmohamed;Aldo Grefhorst;Jeffrey Kroon;Laurens Reeskamp;Dipender Gill;Nicholas Wareham;G. Hovingh;Erik Stroes;Matthijs Boekholdt
  • 通讯作者:
    Matthijs Boekholdt
PLASMA PROTEIN SCANNING AS A NEW TOOL IN PREVENTIVE CARDIOLOGY
  • DOI:
    10.1016/s0735-1097(20)32646-2
  • 发表时间:
    2020-03-24
  • 期刊:
  • 影响因子:
  • 作者:
    Rachel Ostroff;Claudia Langenberg;Nicholas Wareham;Peter Ganz;Mika Kivimaki;Claude Bouchard;Christian Jonasson;Leigh Alexander;Jessica Chadwick;Gargi Datta;Yolanda Hagar;Michael Hinterberg;Stephen A. Williams
  • 通讯作者:
    Stephen A. Williams
Refinement of post-COVID condition core symptoms, subtypes, determinants, and health impacts: a cohort study integrating real-world data and patient-reported outcomes
新冠后状况核心症状、亚型、决定因素和健康影响的细化:一项整合真实世界数据和患者报告结果的队列研究
  • DOI:
    10.1016/j.ebiom.2024.105493
  • 发表时间:
    2025-01-01
  • 期刊:
  • 影响因子:
    10.800
  • 作者:
    Yunhe Wang;Marta Alcalde-Herraiz;Kim López Güell;Li Chen;Lourdes Mateu;Chunxiao Li;Raghib Ali;Nicholas Wareham;Roger Paredes;Daniel Prieto-Alhambra;Junqing Xie
  • 通讯作者:
    Junqing Xie

Nicholas Wareham的其他文献

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{{ truncateString('Nicholas Wareham', 18)}}的其他基金

Director of population health improvement network of clusters
集群人口健康改善网络主任
  • 批准号:
    MR/Y033914/1
  • 财政年份:
    2024
  • 资助金额:
    $ 170.87万
  • 项目类别:
    Research Grant
Developing and disseminating tools for population health improvement: an online interactive atlas for identifying environmental change
开发和传播改善人口健康的工具:用于识别环境变化的在线交互式地图集
  • 批准号:
    MC_PC_21024
  • 财政年份:
    2022
  • 资助金额:
    $ 170.87万
  • 项目类别:
    Intramural
The EPIC-Norfolk Study
EPIC-诺福克研究
  • 批准号:
    MC_PC_21036
  • 财政年份:
    2021
  • 资助金额:
    $ 170.87万
  • 项目类别:
    Intramural
Aetiology and Mechanisms of Diabetes and Related Metabolic Disorders of Later Life
糖尿病及晚年相关代谢紊乱的病因和机制
  • 批准号:
    MC_UU_00006/1
  • 财政年份:
    2020
  • 资助金额:
    $ 170.87万
  • 项目类别:
    Intramural
Non-communicable disease epidemiology and public health
非传染性疾病流行病学和公共卫生
  • 批准号:
    ES/N013891/1
  • 财政年份:
    2015
  • 资助金额:
    $ 170.87万
  • 项目类别:
    Research Grant
Aetiology of type 2 diabetes and related metabolic disorders
2 型糖尿病和相关代谢紊乱的病因学
  • 批准号:
    MC_UU_12015/1
  • 财政年份:
    2013
  • 资助金额:
    $ 170.87万
  • 项目类别:
    Intramural
High Throughput Science - Investigating pathways to metabolic disease using "omic" approaches
高通量科学 - 使用“组学”方法研究代谢疾病的途径
  • 批准号:
    MC_PC_13046
  • 财政年份:
    2013
  • 资助金额:
    $ 170.87万
  • 项目类别:
    Intramural
Part of the Cambridge Initiative in metabolic science to enhance the Epidemiology Unit’s existing research programmes.
这是剑桥代谢科学倡议的一部分,旨在加强流行病学部门现有的研究项目。
  • 批准号:
    MC_EX_MR/L100002/1
  • 财政年份:
    2013
  • 资助金额:
    $ 170.87万
  • 项目类别:
    Intramural
Centre for Diet and Activity Research (CEDAR)
饮食和活动研究中心 (CEDAR)
  • 批准号:
    MR/K023187/1
  • 财政年份:
    2013
  • 资助金额:
    $ 170.87万
  • 项目类别:
    Research Grant
MRC-GSK pilot programme to identify new targets and biomarkers from genetic association studies
MRC-GSK 试点计划从遗传关联研究中确定新靶标和生物标志物
  • 批准号:
    G0701863/1
  • 财政年份:
    2008
  • 资助金额:
    $ 170.87万
  • 项目类别:
    Research Grant

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  • 项目类别:
    Continuing Grant
CAREER: Investigating and Supporting Undergraduate Biology Students' Abilities to Communicate about Culturally Controversial Science Topics
职业:调查和支持生物学本科生交流有文化争议的科学话题的能力
  • 批准号:
    2238174
  • 财政年份:
    2023
  • 资助金额:
    $ 170.87万
  • 项目类别:
    Continuing Grant
Investigating the Impact of a District-Wide Implementation of Science Curricula on Science Teachers Effectiveness and Retention
调查全区范围内实施科学课程对科学教师的有效性和保留率的影响
  • 批准号:
    2151150
  • 财政年份:
    2022
  • 资助金额:
    $ 170.87万
  • 项目类别:
    Continuing Grant
ECR Core Research: Investigating Computer Science Departmental Diversity Efforts to Identify Levers for Change
ECR 核心研究:调查计算机科学部门的多元化努力,以确定变革的杠杆
  • 批准号:
    2200706
  • 财政年份:
    2022
  • 资助金额:
    $ 170.87万
  • 项目类别:
    Continuing Grant
Collaborative Research: Science with the OVRO-LWA -- Investigating Space Weather in Young Stellar Systems
合作研究:与 OVRO-LWA 的科学——研究年轻恒星系统中的空间天气
  • 批准号:
    2206590
  • 财政年份:
    2022
  • 资助金额:
    $ 170.87万
  • 项目类别:
    Standard Grant
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