Aetiology of type 2 diabetes and related metabolic disorders

2 型糖尿病和相关代谢紊乱的病因学

• 批准号: MC_UU_12015/1
• 负责人: Nicholas Wareham
• 金额: $ 707.56万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_12015%2F1
• 关键词: Aetiology; type; diabetes; related; metabolic

It is suggested that type 2 diabetes arises from a complex interaction between genetic factors, obesity and lifestyle factors such as dietary behaviour and physical activity but the detailed mechanisms underlying these interactions have not been identified. We aim to study the interplay between these factors using a range of different epidemiological study designs across multiple studies around the world. We aim to identify genetic variants associated with risk of type 2 diabetes and related metabolic traits which can identify novel pathways to disease. Identification of these pathways can enable development of new therapies to help prevent and treat type 2 diabetes. A broad range of lifestyle, behavioural, anthropometric and biological risk factors are associated with future risk of type 2 diabetes. However, before we intervene on any of these risk factors, it is important to understand which ones are causal (i.e. would changing the risk factor actually result in reductions in risk?). Through the use of genetics, we can prioritise which of these risk factors is most likely to be causal and thereby define which risk factors are likely to be most fruitful for intervention.

研究表明，2型糖尿病是由遗传因素、肥胖和生活方式因素（如饮食行为和体育活动）之间复杂的相互作用引起的，但这些相互作用的详细机制尚未确定。我们的目标是在世界各地的多项研究中使用一系列不同的流行病学研究设计来研究这些因素之间的相互作用。我们的目标是识别与2型糖尿病风险相关的遗传变异和相关的代谢特征，这些特征可以识别疾病的新途径。识别这些途径可以开发新的治疗方法，以帮助预防和治疗2型糖尿病。广泛的生活方式，行为，人体测量和生物学风险因素与2型糖尿病的未来风险相关。然而，在我们干预任何这些风险因素之前，重要的是要了解哪些是因果关系（即改变风险因素实际上会导致风险降低吗？）。通过使用遗传学，我们可以优先考虑哪些风险因素最有可能是因果关系，从而确定哪些风险因素可能是最有效的干预措施。

项目成果

Tinned fruit consumption and mortality in three prospective cohorts.

• DOI: 10.1371/journal.pone.0117796
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Aasheim ET;Sharp SJ;Appleby PN;Shipley MJ;Lentjes MA;Khaw KT;Brunner E;Key TJ;Wareham NJ
• 通讯作者: Wareham NJ

Circulating peroxiredoxin 4 and type 2 diabetes risk: the Prevention of Renal and Vascular Endstage Disease (PREVEND) study.

• DOI: 10.1007/s00125-014-3278-9
• 发表时间: 2014-09
• 期刊: DIABETOLOGIA
• 影响因子: 8.2
• 作者: Abbasi, Ali;Corpeleijn, Eva;Gansevoort, Ron T.;Gans, Rijk O. B.;Struck, Joachim;Schulte, Janin;Hillege, Hans L.;van der Harst, Pim;Stolk, Ronald P.;Navis, Gerjan;Bakker, Stephan J. L.
• 通讯作者: Bakker, Stephan J. L.

Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: the EPIC-InterAct study.

• DOI: 10.1038/ejcn.2013.235
• 发表时间: 2014-02
• 期刊: European journal of clinical nutrition
• 影响因子: 4.7

Comment on Vassy et al. polygenic type 2 diabetes prediction at the limit of common variant detection. Diabetes 2014;63:2172-2182.

对 Vassy 等人的评论

• DOI: 10.2337/db14-0271
• 发表时间: 2014
• 期刊: Diabetes
• 影响因子: 7.7
• 作者: Abbasi A

Mendelian randomization studies of biomarkers and type 2 diabetes.

• DOI: 10.1530/ec-15-0087
• 发表时间: 2015-12
• 期刊: Endocrine connections
• 影响因子: 2.9
• 作者: Abbasi A