Definition of the differential proliferative tissue damaging and transcriptional responses in endogenously TCR- triggered lymphocytes versus foreign antigen stimulated lymphocytes induced by checkpoint blockade

内源性 TCR 触发淋巴细胞与检查点封锁诱导的外来抗原刺激淋巴细胞中差异增殖组织损伤和转录反应的定义

• 批准号: MC_EX_MR/S300011/1
• 负责人: James Thaventhiran
• 金额: $ 63.71万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_EX_MR%2FS300011%2F1
• 关键词: Definition; differential; proliferative; tissue; damaging

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前GtR中并没有所有资助研究的摘要。这通常是因为在提交提案时不需要摘要，但也可能是因为摘要中包含个人详细信息等敏感信息。

项目成果

Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data.

端粒：一种倍性 - 敏锐的方法，用于从整个基因组测序数据中估算端粒长度。

• DOI: 10.1038/s41598-017-14403-y
• 发表时间: 2018-01-22
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Farmery JHR;Smith ML;NIHR BioResource - Rare Diseases;Lynch AG
• 通讯作者: Lynch AG

Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort.

出版商更正：散发性原发性免疫缺陷队列的全基因组测序。

• DOI: 10.1038/s41586-020-2556-6
• 发表时间: 2020
• 期刊: Nature
• 影响因子: 64.8
• 作者: Thaventhiran JED

CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response.

• DOI: 10.1073/pnas.2013644117
• 发表时间: 2020-11-17
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: Biasci D;Smoragiewicz M;Connell CM;Wang Z;Gao Y;Thaventhiran JED;Basu B;Magiera L;Johnson TI;Bax L;Gopinathan A;Isherwood C;Gallagher FA;Pawula M;Hudecova I;Gale D;Rosenfeld N;Barmpounakis P;Popa EC;Brais R;Godfrey E;Mir F;Richards FM;Fearon DT;Janowitz T;Jodrell DI
• 通讯作者: Jodrell DI

Inborn errors of IL-6 family cytokine responses.

• DOI: 10.1016/j.coi.2021.04.007
• 发表时间: 2021-10
• 期刊: Current opinion in immunology
• 影响因子: 7
• 作者: Chen YH;Spencer S;Laurence A;Thaventhiran JE;Uhlig HH
• 通讯作者: Uhlig HH

Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report.

• DOI: 10.1038/s41467-020-19761-2
• 发表时间: 2020-12-14
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Buckland MS;Galloway JB;Fhogartaigh CN;Meredith L;Provine NM;Bloor S;Ogbe A;Zelek WM;Smielewska A;Yakovleva A;Mann T;Bergamaschi L;Turner L;Mescia F;Toonen EJM;Hackstein CP;Akther HD;Vieira VA;Ceron-Gutierrez L;Periselneris J;Kiani-Alikhan S;Grigoriadou S;Vaghela D;Lear SE;Török ME;Hamilton WL;Stockton J;Quick J;Nelson P;Hunter M;Coulter TI;Devlin L;CITIID-NIHR COVID-19 BioResource Collaboration;MRC-Toxicology Unit COVID-19 Consortium;Bradley JR;Smith KGC;Ouwehand WH;Estcourt L;Harvala H;Roberts DJ;Wilkinson IB;Screaton N;Loman N;Doffinger R;Lyons PA;Morgan BP;Goodfellow IG;Klenerman P;Lehner PJ;Matheson NJ;Thaventhiran JED
• 通讯作者: Thaventhiran JED