SARS COV2 vaccine ResPonse In Obesity - SCORPIO study

SARS COV2 疫苗对肥胖的反应 - SCORPIO 研究

• 批准号: MR/W020564/1
• 负责人: James Thaventhiran
• 金额: $ 95.86万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FW020564%2F1
• 关键词: SARS; COV2; vaccine; ResPonse; Obesity

The best way to protect people from COVID-19 is by vaccination. Vaccines trigger a person's immune system so it is primed to respond efficiently if the person comes into contact with the virus again. It is important to know whether vaccines against the SARS-CoV-2 virus, which causes COVID-19, work as well in people with underlying health conditions as they do in healthy people. The aim of this study is to test whether the SARS-CoV-2 vaccine works equally well in people with weight problems and diabetes. People who are overweight/obese and those who have diabetes are much more likely to become seriously ill if they develop COVID-19 infection. If vaccines don't work as well, then 10 million people in the UK will still be at high risk of COVID-19 infection, when they think they are protected. By bringing together world-leading doctors and researchers in obesity/diabetes and infection/immunity, this research project will establish whether the immune response is different in people who are overweight or have diabetes. Previous research with other vaccines such as the flu vaccine, suggests that the immune response might be weaker or may not last as long in people with these health conditions. We think it is likely that some people with obesity/diabetes will have a weak immune response and we want to see if losing weight can boost the vaccine response. If it does, then this would provide a strong incentive for extra help and support for weight loss treatments, which are currently only available to a small number of people who have really struggled with their weight for decades. Over the next year, we will invite 200 people who are having different weight loss treatments (intense diet and surgery) as part of their routine medical care to take part in the SCORPIO study. If they agree, we will take a few extra blood samples to look at whether their vaccine response changes after weight loss treatment. We will collect information about their height and weight, medical conditions and look in detail at the immune system, blood sugar levels and hormones. Based on our experience, it is likely some people will lose a small amount of weight while others will lose a lot of weight. We will study the impact of weight loss on the immune response to the first and second dose of the COVID-19 vaccine. We will keep a close eye on people in the study during their regular clinic visits and if they develop symptoms of COVID-19 infection, we will ensure they receive prompt medical care. We will also arrange for genetic sequencing to see if particular variants of the virus are affecting people with weight problems and diabetes.We will compare these results with normal weight people based locally and compare these results with colleagues around the country to make best use of the available informationAt the end of the study, we will establish whether the immune response is weaker in people with obesity/diabetes, which groups of people are most at risk (e.g. is it people with the highest blood sugars?) and find out if weight loss can rapidly improve the immune response to the vaccine, giving people better protection against COVID-19.

保护人们免受COVID-19感染的最佳方法是接种疫苗。疫苗会触发一个人的免疫系统，因此如果这个人再次接触病毒，免疫系统就会做出有效的反应。重要的是要知道针对导致COVID-19的SARS-CoV-2病毒的疫苗是否在有潜在健康状况的人身上也能像在健康人身上一样有效。这项研究的目的是测试SARS-CoV-2疫苗是否对体重问题和糖尿病患者同样有效。超重/肥胖和糖尿病患者如果感染COVID-19，更有可能患重病。如果疫苗效果不佳，那么英国仍有1000万人处于COVID-19感染的高风险之中，而他们认为自己受到了保护。通过汇集世界领先的肥胖/糖尿病和感染/免疫领域的医生和研究人员，该研究项目将确定超重或糖尿病患者的免疫反应是否不同。以前对其他疫苗（如流感疫苗）的研究表明，免疫反应可能较弱，或者在患有这些健康状况的人中可能不会持续很长时间。我们认为一些肥胖/糖尿病患者的免疫反应很可能很弱，我们想看看减肥是否能提高疫苗的反应。如果是这样的话，那么这将为减肥治疗提供额外的帮助和支持提供强大的激励，目前只有少数人真正与体重斗争了几十年。在接下来的一年里，我们将邀请200名正在接受不同减肥治疗（高强度饮食和手术）的人参加Scorpio研究。如果他们同意，我们将采取一些额外的血液样本，看看他们的疫苗反应是否在减肥治疗后发生变化。我们将收集有关他们的身高和体重，医疗状况的信息，并详细了解免疫系统，血糖水平和激素。根据我们的经验，很可能有些人会减掉少量的体重，而另一些人会减掉很多体重。我们将研究体重减轻对第一剂和第二剂COVID-19疫苗免疫反应的影响。我们将在研究中的患者定期就诊期间密切关注他们，如果他们出现COVID-19感染的症状，我们将确保他们得到及时的医疗护理。我们还将安排基因测序，看看是否有特定的病毒变种正在影响体重问题和糖尿病患者。我们将把这些结果与当地正常体重的人进行比较，并将这些结果与全国各地的同事进行比较，以充分利用现有的信息。在研究结束时，我们将确定肥胖/糖尿病患者的免疫反应是否较弱，哪些人群风险最高（例如，血糖最高的人群？）并了解减肥是否能迅速提高对疫苗的免疫反应，从而更好地保护人们免受COVID-19的侵害。

项目成果

Accelerated waning of the humoral response to COVID-19 vaccines in obesity.

• DOI: 10.1038/s41591-023-02343-2
• 发表时间: 2023-05
• 期刊: NATURE MEDICINE
• 影响因子: 82.9
• 作者: van der Klaauw, Agatha C.;Horner, Emily;Pereyra-Gerber, Pehuen;Agrawal, Utkarsh S.;Foster, William;Spencer, Sarah;Vergese, Bensi;Smith, Miriam;Henning, Elana D.;Ramsay, Isobel A.;Smith, Jack M.;Guillaume, Stephane J.;Sharpe, Hayley M.;Hay, Iain;Thompson, Sam;Innocentin, Silvia H.;Booth, Lucy;Robertson, Chris;McCowan, Colin;Kerr, Steven;Mulroney, Thomas J.;O'Reilly, Martin P.;Gurugama, Thevinya P.;Gurugama, Lihinya A.;Rust, Maria;Ferreira, Alex;Ebrahimi, Soraya;Ceron-Gutierrez, Lourdes;Scotucci, Jacopo;Kronsteiner, Barbara J.;Dunachie, Susanna;Klenerman, Paul J.;Park, Adrian A.;Rubino, Francesco;Lamikanra, Abigail;Stark, Hannah;Kingston, Nathalie;Estcourt, Lise;Harvala, Heli;Roberts, David A.;Doffinger, Rainer J.;Linterman, Michelle;Matheson, Nicholas;Sheikh, Aziz;Farooqi, I. Sadaf;Thaventhiran, James E. D.
• 通讯作者: Thaventhiran, James E. D.

Inborn errors of IL-6 family cytokine responses.

• DOI: 10.1016/j.coi.2021.04.007
• 发表时间: 2021-10
• 期刊: Current opinion in immunology
• 影响因子: 7
• 作者: Chen YH;Spencer S;Laurence A;Thaventhiran JE;Uhlig HH
• 通讯作者: Uhlig HH

Atypical B cells and impaired SARS-CoV-2 neutralization following heterologous vaccination in the elderly.

• DOI: 10.1016/j.celrep.2023.112991
• 发表时间: 2023-08
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: I. Ferreira;C. Q. Lee;W. Foster;A. Abdullahi;L. Dratva;Z. Tuong;B. Stewart;J. Ferdinand;Stephane M. Guillaume;Martin Potts;Marianne R Perera;Ben Krishna;Ana Ivis Peñalver;Mia Cabantous;S. Kemp;L. Ceron-Gutierrez;S. Ebrahimi;P. Lyons;Ken G. C. Smith;J. Bradley;D. Collier;L. McCoy;A. A. van der Klaauw-A.;James E. D. Thaventhiran;I. Farooqi;Sarah A. Teichmann;P. MacAry;R. Doffinger;M. Wills;M. Linterman;M. Clatworthy;Ravindra K. Gupta

Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens.

• DOI: 10.1016/j.medj.2023.02.004
• 发表时间: 2023-03-10
• 期刊: MED
• 影响因子: 17
• 作者: Moore, Shona C.;Kronsteiner, Barbara;Longet, Stephanie;Adele, Sandra;Deeks, Alexandra S.;Liu, Chang;Dejnirattisai, Wanwisa;Reyes, Laura Silva;Meardon, Naomi;Faustini, Sian;Al-Taei, Saly;Tipton, Tom;Hering, Luisa M.;Angyal, Adrienn;Brown, Rebecca;Nicols, Alexander R.;Dobson, Susan L.;Supasa, Piyada;Tuekprakhon, Aekkachai;Cross, Andrew;Tyerman, Jessica K.;Hornsby, Hailey;Grouneva, Irina;Plowright, Megan;Zhang, Peijun;Newman, Thomas A. H.;Nell, Jeremy M.;Abraham, Priyanka;Ali, Mohammad;Malone, Tom;Neale, Isabel;Phillips, Eloise;Wilson, Joseph D.;Murray, Sam M.;Zewdie, Martha;Shields, Adrian;Horner, Emily C.;Booth, Lucy H.;Stafford, Lizzie;Bibi, Sagida;Wootton, Daniel G.;Mentzer, Alexander J.;Conlon, Christopher P.;Jeffery, Katie;Matthews, Philippa C.;Pollard, Andrew J.;Brown, Anthony;Rowland-Jones, Sarah L.;Mongkolsapaya, Juthathip;Payne, Rebecca P.;Dold, Christina;Lambe, Teresa;Thaventhiran, James E. D.;Screaton, Gavin;Barnes, Eleanor;Hopkins, Susan;Hall, Victoria;Ducan, Christopher J. A.;Richter, Alex;Carroll, Miles;de Silva, Thushan I.;Klenerman, Paul;Dunachie, Susann;Turtle, Lance;PITCH Consortium
• 通讯作者: PITCH Consortium