OCULOMOTOR DISORDERS IN HUMAN SUBJECTS

人类受试者的眼动障碍

• 批准号: 4693339
• 负责人: J N CURRIE
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4693339
• 关键词: Alzheimer's disease; Kallmann's syndrome; caffeine; cerebellar disorders; clonazepam; electrooculography; eye accommodation; eye disorder chemotherapy; eye disorder diagnosis; eye movement disorders; human subject; neuromuscular disorder diagnosis; nystagmus; postural hypotension; vision disorders; visual stimulus

Oscillopsia and reduced visual acuity due to retinal image slip caused by acquired nystagmus, and in particular by downbeating nystagmus, can be temporarily reduced or eliminated by a single dose of clonazepam and a sustained beneficial effect can be obtained with daily use of clonazepam. Ocular motor abnormalities in Kallman's syndrome suggest that dysfunction of the cerebellar vermis may also be part of this syndrome. Eye movement abnormalities in multisystem atrophy (Shy-Drager Syndrome) and olivoponto-cerebellar atrophy were studied to provide diagnostic and prognostic information. Studies of eye movements in patients with familial Alzheimer's disease and their first order (at risk) relatives attempt to provide additional diagnostic, prognostic and therapeutic monitoring information. Saccadic velocities have been shown to be a sensitive indicator of benzodiazepine drug effects in man. Caffeine acts as a benzodiazepine antagonist for the degradation of saccadic velocities but not for cognitive function, suggesting different benzodiazepine receptor functions for these two parameters. Carbamazepine induced downbeating nystagmus in two patients without craniocervical abnormalities and this resolved when carbamazepine levels were reduced.

由于视网膜图像滑动引起的振动视和视力下降 获得性眼球震颤，特别是通过抑制性眼球震颤，可以 通过单剂量氯硝西泮和 每天使用氯硝西泮可以获得持续的有益效果。 卡尔曼综合征的眼部运动异常表明功能障碍 小脑蚓部的病变也可能是该综合征的一部分。 眼球运动 多系统萎缩异常（Shy-Drager 综合征）和 研究橄榄桥小脑萎缩以提供诊断和 预后信息。 家族性遗传病患者眼球运动研究 阿尔茨海默病及其一级（有风险）亲属试图 提供额外的诊断、预后和治疗监测 信息。 扫视速度已被证明是一个敏感指标 苯二氮卓类药物对人类的影响。 咖啡因充当苯二氮卓类药物 拮抗剂可以降低眼跳速度，但不能降低认知能力 功能，表明这些药物具有不同的苯二氮卓受体功能 两个参数。 卡马西平在两名无症状的患者中诱发了抑郁性眼球震颤 颅颈异常，当卡马西平水平升高时该问题得到解决 减少了。