PUPILLARY FUNCTION IN HUMAN SUBJECTS

人类受试者的瞳孔功能

• 批准号: 4693381
• 负责人: J N CURRIE
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4693381
• 关键词: Horner's syndrome; aging; autonomic disorder; dark adaptation; human subject; light adaptations; mydriatic /cycloplegic; parasympathetic nervous system; pilocarpine; postural hypotension; pupillary reflex; sympathetic nervous system

Normative values were derived for the effects of different doses of dilute pilocarpine on pupil diameter, and these were used to study denervation supersensitivity in both pre- and postganglionic parasympathetic lesions. Patients with Shy Drager syndrome and alternating Horner's syndrome were studied to determine the possible mechanisms for this abnormality. A study of the effect of light and darkness on pupil diameter in Horner's syndrome revealed that anisocoria is not necessarily greater in darkness, as had been previously thought. Studies were made on the effects of aging on pupil size and parasympathetic and sympathetic reactivity. The phenomenon of paradoxical pupillary constriction in darkness was studied in three patients with rod monochromatism.

得出了不同剂量稀释剂影响的标准值 匹罗卡品对瞳孔直径的影响，并将其用于研究失神经 节前和节后副交感神经病变的超敏反应。 Shy Drager综合征和交替Horner综合征的患者 研究以确定这种异常的可能机制。一项研究 光暗对霍纳综合征患者瞳孔直径的影响 揭示了不等角眼在黑暗中不一定比以前更严重。 之前的想法是。 研究了年龄对瞳孔大小和副交感神经的影响。 以及共鸣的反应性。 在黑暗中，反常的瞳孔收缩现象是 对3名杆状单色性眼病患者进行了研究。