Determinants of sustained virological response after discontinuation of long-term nucleoside analogue therapy in chronic hepatitis B patients

慢性乙型肝炎患者停止长期核苷类似物治疗后持续病毒学应答的决定因素

• 批准号: nhmrc : 1066536
• 负责人: A/Pr Paul Desmond
• 金额: $ 65.13万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/determinants-sustained-virological-b-patients/455241
• 关键词: Determinants; sustained; virological; response; after

Guidelines currently recommend lifelong treatment for patients with chronic hepatitis B, with associated cost and risks of drug resistance and side effects. It has recently been suggested that up to 50% of patients may safely and successfully stop drug after long-term treatment. Our project will identify which patients can safely stop treatment, by performing detailed studies of the human immune system and the hepatitis B virus. This will be an important advance for patient care.

目前，指南建议对慢性乙型肝炎患者进行终身治疗，同时考虑到相关的费用和耐药及副作用风险。最近有人建议，在长期治疗后，高达50%的患者可以安全并成功地停药。我们的项目将通过对人体免疫系统和乙型肝炎病毒进行详细研究，确定哪些患者可以安全地停止治疗。这将是病人护理的一个重要进步。