Healthcare Workers: an in depth virological analysis and behavioural study during the outbreak

医护人员：疫情爆发期间的深入病毒学分析和行为研究

• 批准号: MC_PC_19082
• 负责人: Eleni Nastouli
• 金额: $ 186.52万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_19082
• 关键词: Healthcare; Workers; depth; virological; analysis

Coronaviruses transmit easily, the disease is highly infectious and can lead to serious illness and death. Healthcare workers becoming ill in large numbers would have a huge impact on health care provision. Bed shortages in over-stretched hospitals are common and the additional burden from coronavirus could bring staff to breaking point. We had a unique opportunity in 2017/8 to investigate healthcare workers at University College London Hospitals (UCLH) infected with influenza compared to those who were well. There is lack of evidence around the risk of coronavirus so we now propose a study that will examine the rates at which healthcare workers become infected with coronavirus in three wards and A/E at UCLH, using the same methods as before. We will also interview healthcare workers to find out their challenges in preventing infection spreading to themselves, other staff and patients, while working during a novel pathogen outbreak. We will use antigen tests to rapidly screen them to see if they are infected with coronavirus, and complement these with antibody tests. This information will add significantly to the understanding of staff health and safety, hospital infection prevention and control, and will improve the evidence-base for the protection of patients and staff.

冠状病毒很容易传播，这种疾病传染性很强，可能会导致严重的疾病和死亡。医护人员大量患病将对医疗保健的提供产生巨大影响。超负荷的医院床位短缺是很常见的，冠状病毒带来的额外负担可能会使工作人员达到临界点。在2017/8年度，我们有一个独特的机会调查伦敦大学学院医院(UCLH)感染流感的医护人员与那些健康的医护人员。关于冠状病毒的风险缺乏证据，因此我们现在提议进行一项研究，使用与以前相同的方法，检查三个病房的医护人员感染冠状病毒的比率和UCLH的A/E感染比率。我们还将采访医护人员，以了解他们在一场新的病原体爆发期间工作时，在防止感染传播给自己、其他工作人员和患者方面面临的挑战。我们将使用抗原测试来快速筛查他们是否感染了冠状病毒，并辅之以抗体测试。这些信息将大大增加对工作人员健康和安全、医院感染预防和控制的了解，并将改善保护患者和工作人员的证据基础。

项目成果

Estimating the effectiveness of routine asymptomatic PCR testing at different frequencies for the detection of SARS-CoV-2 infections.

• DOI: 10.1186/s12916-021-01982-x
• 发表时间: 2021-04-27
• 期刊: BMC medicine
• 影响因子: 9.3
• 作者: Hellewell J;Russell TW;SAFER Investigators and Field Study Team;Crick COVID-19 Consortium;CMMID COVID-19 working group;Beale R;Kelly G;Houlihan C;Nastouli E;Kucharski AJ
• 通讯作者: Kucharski AJ

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans.

对人类的SARS-COV-2的先前和从头触觉免疫。

• DOI: 10.1126/science.abe1107
• 发表时间: 2020-12-11
• 期刊: Science (New York, N.Y.)
• 作者: Ng KW;Faulkner N;Cornish GH;Rosa A;Harvey R;Hussain S;Ulferts R;Earl C;Wrobel AG;Benton DJ;Roustan C;Bolland W;Thompson R;Agua-Doce A;Hobson P;Heaney J;Rickman H;Paraskevopoulou S;Houlihan CF;Thomson K;Sanchez E;Shin GY;Spyer MJ;Joshi D;O'Reilly N;Walker PA;Kjaer S;Riddell A;Moore C;Jebson BR;Wilkinson M;Marshall LR;Rosser EC;Radziszewska A;Peckham H;Ciurtin C;Wedderburn LR;Beale R;Swanton C;Gandhi S;Stockinger B;McCauley J;Gamblin SJ;McCoy LE;Cherepanov P;Nastouli E;Kassiotis G
• 通讯作者: Kassiotis G

The effect of spike mutations on SARS-CoV-2 neutralization.

• DOI: 10.1016/j.celrep.2021.108890
• 发表时间: 2021-03-23
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Rees-Spear C;Muir L;Griffith SA;Heaney J;Aldon Y;Snitselaar JL;Thomas P;Graham C;Seow J;Lee N;Rosa A;Roustan C;Houlihan CF;Sanders RW;Gupta RK;Cherepanov P;Stauss HJ;Nastouli E;SAFER Investigators;Doores KJ;van Gils MJ;McCoy LE
• 通讯作者: McCoy LE

Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains.

• DOI: 10.7554/elife.69317
• 发表时间: 2021-07-29
• 期刊: eLife
• 影响因子: 7.7
• 作者: Faulkner N;Ng KW;Wu MY;Harvey R;Margaritis M;Paraskevopoulou S;Houlihan C;Hussain S;Greco M;Bolland W;Warchal S;Heaney J;Rickman H;Spyer M;Frampton D;Byott M;de Oliveira T;Sigal A;Kjaer S;Swanton C;Gandhi S;Beale R;Gamblin SJ;McCauley JW;Daniels RS;Howell M;Bauer D;Nastouli E;Kassiotis G
• 通讯作者: Kassiotis G

Additional file 1 of Estimating the effectiveness of routine asymptomatic PCR testing at different frequencies for the detection of SARS-CoV-2 infections

附加文件 1：评估不同频率的常规无症状 PCR 检测对 SARS-CoV-2 感染检测的有效性

• DOI: 10.6084/m9.figshare.14489977
• 发表时间: 2021
• 作者: Hellewell J