COVID-19: Data and Connectivity – National Core Study (D&C-NCS)

COVID-19：数据和连接 – 国家核心研究 (D

• 批准号: MC_PC_20029
• 负责人: Andrew Morris
• 金额: $ 1048.67万
• 依托单位: Health Data Research UK
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_20029
• 关键词: COVID; 19; Data; Connectivity; National

The COVID-19 Data and Connectivity National Core Study will build a national health data research capability to support priority COVID-19 research questions. It draws on lessons for health data research which have been learnt from COVID, showing how urgency and focus during the pandemic have enabled data to be used to generate insights that transformed our knowledge of COVID-19. These lessons highlighted significant challenges with data access, fragmentation, the importance of transparency and concerns over inherent inequalities and sustainability across approaches. The COVID-19 Data and Connectivity National Core Study will therefore ensure needed datasets are discoverable and accessible and linkages are established to answer the research questions prioritised by the five National Core Studies. These research questions and the supporting data and connectivity infrastructure will be critical in provisioning for the longer-term response to COVID. Delivery of the COVID-19 Data and Connectivity Study will involve close interaction with data custodians, the public and patients, and providers of UK-wide national Trusted Research Environments (TREs) to ensure the required data is stored safely and securely, made readily available to approved researchers and is associated with compute, analytical and data services that make it easier to address priority research questions in a transparent and trustworthy way.

新冠肺炎数据和互联互通国家核心研究将建设国家健康数据研究能力，以支持新冠肺炎优先研究问题。它借鉴了从COVID学到的卫生数据研究的经验教训，展示了大流行期间的紧迫性和重点如何使数据能够被用来产生洞察力，从而改变了我们对新冠肺炎的知识。这些经验教训突出了在数据获取、碎片化、透明度的重要性以及对各种办法固有的不平等和可持续性的关切方面的重大挑战。因此，新冠肺炎数据和互联互通国家核心研究将确保所需的数据集是可发现和可访问的，并建立联系，以回答五项国家核心研究优先考虑的研究问题。这些研究问题以及支持性数据和连接基础设施将是为应对COVID的长期应对措施提供资源的关键。新冠肺炎数据与互联互通研究的交付将涉及与数据托管人、公众和患者以及英国全国可信研究环境(TRES)的提供商密切互动，以确保所需数据安全可靠地存储，供经批准的研究人员随时使用，并与计算、分析和数据服务相关联，从而更容易以透明和值得信赖的方式解决优先研究问题。

项目成果

Impact of COVID-19 lockdown on the incidence and mortality of acute exacerbations of chronic obstructive pulmonary disease: national interrupted time series analyses for Scotland and Wales.

• DOI: 10.1186/s12916-021-02000-w
• 发表时间: 2021-05-17
• 期刊: BMC medicine
• 影响因子: 9.3
• 作者: Alsallakh MA;Sivakumaran S;Kennedy S;Vasileiou E;Lyons RA;Robertson C;Sheikh A;Davies GA;EAVE II Collaborators
• 通讯作者: EAVE II Collaborators

COVID-19 booster vaccination uptake and infection breakthrough amongst health care workers in Wales: A national prospective cohort study.

• DOI: 10.1016/j.vaccine.2023.01.023
• 发表时间: 2023-02-10
• 期刊: VACCINE
• 影响因子: 5.5
• 作者: Bedston, Stuart;Lowthian, Emily;Jarvis, Christopher I;Akbari, Ashley;Beggs, Jillian;Bradley, Declan;de Lusignan, Simon;Griffiths, Rowena;Herbert, Laura;Hobbs, Richard;Kerr, Steven;Lyons, Jane;Midgley, William;Owen, Rhiannon K;Quint, Jennifer K;Tsang, Ruby;Torabi, Fatemeh;Sheikh, Aziz;Lyons, Ronan A
• 通讯作者: Lyons, Ronan A

Post-vaccination SARS-CoV-2 infection: risk factors and illness profile in a prospective, observational community-based case-control study

疫苗接种后 SARS-CoV-2 感染：基于社区的前瞻性、观察性病例对照研究中的危险因素和疾病概况

• DOI: 10.1101/2021.05.24.21257738
• 发表时间: 2021
• 作者: Antonelli M

Pathways explaining racial/ethnic and socio-economic disparities in dementia incidence: the UK Biobank study.

• DOI: 10.18632/aging.205058
• 发表时间: 2023-09-25
• 期刊: AGING-US
• 影响因子: 5.2
• 作者: Beydoun, May A.;Beydoun, Hind A.;Fanelli-Kuczmarski, Marie T.;Weiss, Jordan;Georgescu, Michael F.;Meirelles, Osorio;Lyall, Donald M.;Evans, Michele K.;Zonderman, Alan B.
• 通讯作者: Zonderman, Alan B.

PharmGScore scores of compound genetic variant burden for psychiatric treatment optimization

用于优化精神病治疗的复合遗传变异负担的 PharmGScore 评分

• DOI: 10.1101/2023.06.27.23291888
• 发表时间: 2023
• 作者: Borczyk M