MICA: Creating an open access knowledge hub of nutritional biomarkers for use in global health settings

MICA：创建一个开放获取的营养生物标志物知识中心，用于全球健康环境

• 批准号: MC_PC_MR/R019177/1
• 负责人: Sophie Moore
• 金额: $ 18.38万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_MR%2FR019177%2F1
• 关键词: MICA; Creating; open; access; knowledge

Malnutrition, from either under- or over-nutrition, directly affects one in three people globally making malnutrition, together with diet, by far the biggest risk factors for the global burden of disease. Widespread undernutrition and micronutrient deficiencies lead to poor child growth, impaired mental development and reduced adult labour productivity, while a transition towards a more 'westernised' diet is associated with rising rates of obesity and diet related non-communicable diseases. This under- and over-nutrition often coexists to create a 'double-burden' of malnutrition-related health consequences and, with rapid urbanization and the associated nutrition transition, this double burden is most predominant in many low- and middle-income countries (LMICs). To advance understanding of links between diet, nutrition and health in LMICs and to develop and evaluate evidence-based programmes and policies, detailed understanding of nutritional status is required. Existing, community-based studies and surveys from LMIC settings often lack detailed data on individual and population-level nutritional status to inform on policy. Data from critical population categories (e.g. infants, children, adolescents, pregnant and lactation women) are often limited to anthropometry and easy-to-assay parameters (e.g. haemoglobin) or single micronutrients (e.g. vitamin A, iodine). This leads to a knowledge gap to describe the nutritional vulnerabilities in these population groups and hence inform on the design of novel interventions.Modern methods to measure nutritional status have moved away from single nutrient assays requiring relatively large aliquots of blood, access to sample storage facilities, and sophisticated equipment towards 'multiplex' approaches where groups of analytes can be measured in small volumes or on more appropriate matrices, such as dried blood spots. A critical barrier to applying these novel methodologies in LMIC contexts is a lack of easy to access information on their availability and utility and a lack of technical support for the required platforms.In response to this global need, the aim of this application is to bring together expertise in nutritional biomarkers, to create a freely available, online resource (a 'knowledge hub') to support the accurate and detailed assessment of nutritional status in populations from low- and middle-income countries (LMICs). Through a network of academic and industry experts, we will also identify research gaps, where existing methodologies are not practical for implementation in low resource settings or for use in large, population based research in LMICs. The knowledge hub created will enable and support all nutrition and health related research activities in LMICs contributing towards a greater depth of knowledge on the nutritional status of populations in these settings. The longer-term vision of this work is to establish centres of excellence in nutritional assessment methodologies in LMIC settings. Supported by a network of academic, technical and industry experts, these centres will support academic and programmatic research in LMICs, enabling a more comprehensive understanding of the relationship between diet, nutrition and health. Further, where research gaps are identified, we will work with academic and industry partners to develop novel assays to meet the research needs for nutrition and health research globally.

营养不足或营养过剩造成的营养不良直接影响到全球三分之一的人，使营养不良与饮食一起成为迄今为止全球疾病负担的最大风险因素。普遍的营养不良和微量营养素缺乏导致儿童发育不良、智力发育受损和成人劳动生产率降低，而向更“西方化”饮食的过渡与肥胖症和与饮食有关的非传染性疾病的发病率上升有关。这种营养不足和营养过剩往往并存，造成与营养不良有关的健康后果的“双重负担”，随着快速城市化和相关的营养转型，这种双重负担在许多低收入和中等收入国家最为突出。为了进一步了解中低收入国家的饮食、营养和健康之间的联系，并制定和评估基于证据的规划和政策，需要详细了解营养状况。现有的以社区为基础的研究和低收入和中等收入国家的调查往往缺乏关于个人和人口营养状况的详细数据，无法为政策提供信息。来自关键人群类别（如婴儿、儿童、青少年、孕妇和哺乳期妇女）的数据通常仅限于人体测量和易于测定的参数（如血红蛋白）或单一微量营养素（如维生素A、碘）。这导致在描述这些人群的营养脆弱性方面存在知识缺口，从而为设计新的干预措施提供信息。测量营养状况的现代方法已经从需要相对大量的血液、使用样本储存设施和复杂设备的单一营养素分析转向“多重”方法，在这种方法中，可以以小体积或在更合适的基质（如干燥的血点）上测量一组分析物。在低收入和中等收入国家环境中应用这些新方法的一个关键障碍是缺乏关于其可用性和效用的易于获取的信息，以及缺乏对所需平台的技术支持。为了响应这一全球需求，该应用程序的目的是汇集营养生物标志物方面的专业知识，创建一个免费提供的在线资源（“知识中心”），以支持对中低收入国家（LMICs）人口的营养状况进行准确和详细的评估。通过学术和行业专家网络，我们还将确定研究差距，其中现有方法不适合在资源匮乏的环境中实施，也不适合在中低收入国家进行大规模、以人口为基础的研究。所建立的知识中心将使和支持中低收入国家所有与营养和健康有关的研究活动，有助于更深入地了解这些情况下人口的营养状况。这项工作的长期目标是在低收入和中等收入国家建立营养评估方法的卓越中心。在学术、技术和工业专家网络的支持下，这些中心将支持中低收入国家的学术和方案研究，使人们能够更全面地了解饮食、营养和健康之间的关系。此外，在发现研究差距的地方，我们将与学术和工业伙伴合作开发新的检测方法，以满足全球营养和健康研究的研究需求。

项目成果

Effects of Maternal Nutritional Supplements and Dietary Interventions on Placental Complications: An Umbrella Review, Meta-Analysis and Evidence Map.

• DOI: 10.3390/nu13020472
• 发表时间: 2021-01-30
• 期刊: Nutrients
• 影响因子: 5.9
• 作者: Kinshella MW;Omar S;Scherbinsky K;Vidler M;Magee LA;von Dadelszen P;Moore SE;Elango R;The Precise Conceptual Framework Working Group
• 通讯作者: The Precise Conceptual Framework Working Group

The Mothers, Infants, and Lactation Quality (MILQ) Study: A Multi-Center Collaboration.

• DOI: 10.1093/cdn/nzab116
• 发表时间: 2021-10
• 期刊: Current developments in nutrition
• 影响因子: 4.8
• 作者: Allen LH;Hampel D;Shahab-Ferdows S;Andersson M;Barros E;Doel AM;Eriksen KG;Christensen SH;Islam M;Kac G;Keya FK;Michaelsen KF;de Barros Mucci D;Njie F;Peerson JM;Moore SE
• 通讯作者: Moore SE

Increasing the availability and utilization of reliable data on population micronutrient (MN) status globally: the MN Data Generation Initiative.

• DOI: 10.1093/ajcn/nqab173
• 发表时间: 2021-09-01
• 期刊: The American journal of clinical nutrition
• 作者: Brown KH;Moore SE;Hess SY;McDonald CM;Jones KS;Meadows SR;Manger MS;Coates J;Alayon S;Osendarp SJM
• 通讯作者: Osendarp SJM