Immunology of Digestive Disease

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We are working on deciphering mechanisms of sensing of microbes by the immune system and how that is perturbed in diseases such as Crohn’s disease, a major inflammatory bowel disease resulting from breakdown in the normally friendly relationship between microbes present in the bowel and immune cells present in the gut wall. We use large-scale state of the art molecular approaches in primary human cells to decipher molecular pathways that are deranged in inflammatory disease in order to highlight molecules in these pathways that may be amenable to therapeutic manipulation.