Immunology of Digestive Disease

消化系统疾病免疫学

• 批准号: MC_UU_00008/7
• 负责人: Alison Simmons
• 金额: $ 51.1万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00008%2F7
• 关键词: Immunology; Digestive; Disease

We are working on deciphering mechanisms of sensing of microbes by the immune system and how that is perturbed in diseases such as Crohn’s disease, a major inflammatory bowel disease resulting from breakdown in the normally friendly relationship between microbes present in the bowel and immune cells present in the gut wall. We use large-scale state of the art molecular approaches in primary human cells to decipher molecular pathways that are deranged in inflammatory disease in order to highlight molecules in these pathways that may be amenable to therapeutic manipulation.

我们正在努力破译免疫系统对微生物的感知机制，以及这种机制如何在克罗恩病等疾病中受到干扰，克罗恩病是一种主要的炎症性肠病，是由于肠道中存在的微生物与肠道壁中存在的免疫细胞之间的正常友好关系破裂而引起的。我们在原代人类细胞中使用大规模最先进的分子方法来破译炎症性疾病中混乱的分子途径，以突出显示这些途径中可能适合治疗操作的分子。

项目成果

A practical solution for preserving single cells for RNA sequencing.

• DOI: 10.1038/s41598-018-20372-7
• 发表时间: 2018-02-01
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Attar M;Sharma E;Li S;Bryer C;Cubitt L;Broxholme J;Lockstone H;Kinchen J;Simmons A;Piazza P;Buck D;Livak KJ;Bowden R
• 通讯作者: Bowden R

Dual RNA sequencing reveals dendritic cell reprogramming in response to typhoidal Salmonella invasion.

• DOI: 10.1038/s42003-022-03038-z
• 发表时间: 2022-02-04
• 期刊: Communications biology
• 影响因子: 5.9
• 作者: Aulicino A;Antanaviciute A;Frost J;Sousa Geros A;Mellado E;Attar M;Jagielowicz M;Hublitz P;Sinz J;Preciado-Llanes L;Napolitani G;Bowden R;Koohy H;Drakesmith H;Simmons A
• 通讯作者: Simmons A

Baseline Expression of Immune Gene Modules in Blood is Associated With Primary Response to Anti-TNF Therapy in Crohn's Disease Patients.

血液中免疫基因模块的基线表达与克罗恩病患者对抗 TNF 治疗的主要反应相关。

• DOI: 10.1093/ecco-jcc/jjad166
• 发表时间: 2024
• 期刊: Journal of Crohn's & colitis
• 作者: Bai BYH

A Pilot Study on Automatic Three-Dimensional Quantification of Barrett's Esophagus for Risk Stratification and Therapy Monitoring

• DOI: 10.1053/j.gastro.2021.05.059
• 发表时间: 2021-08-18
• 期刊: GASTROENTEROLOGY
• 影响因子: 29.4
• 作者: Ali, Sharib;Bailey, Adam;Braden, Barbara
• 通讯作者: Braden, Barbara

Intracellular immunization against HIV infection with an intracellular antibody that mimics HIV integrase binding to the cellular LEDGF protein.

• DOI: 10.1038/s41598-017-16742-2
• 发表时间: 2017-12-04
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Bao L;Hannon C;Cruz-Mignoni A;Ptchelkine D;Sun MY;Miller A;Bunjobpol W;Quevedo CE;Derveni M;Chambers J;Simmons A;Phillips SEV;Rabbitts TH
• 通讯作者: Rabbitts TH