Cognitive and neurobiological mechanisms underlying memory control.

记忆控制背后的认知和神经生物学机制。

• 批准号: MC_UU_00030/1
• 负责人: Michael Anderson
• 金额: $ 301.48万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00030%2F1
• 关键词: Cognitive; neurobiological; mechanisms; underlying; memory

There is international recognition of the need for a new approach to mental health research that focuses on the mechanistic foundations of symptoms that cut across psychiatric diagnoses rather than diagnostic categories. This programme is uniquely poised to deliver on the promise of this approach. We seek to identify the origins of a crucial trans-diagnostic symptom: perseverative thoughts, in the form of intrusive memories, images, ruminations, pathological worries or obsessive thoughts. Disordered control over thought is amongst the most distressing symptoms of major mental health disorders, such as depression, anxiety, post-traumatic stress disorder and obsessive-compulsive disorder Specifically, we will investigate the ability to stop retrieval of intrusive thoughts via inhibitory control and we seek to understand this fundamental process deeply at the cognitive, systems, and circuit levels. Our ultimate objective is to develop validated treatment targets and practical interventions motivated by high level cognitive theory and innovative neuroscience, which main include interventions based on training, pharmacology, and brain stimulation.

国际社会认识到需要采取新的精神卫生研究方法，重点关注贯穿精神病诊断而不是诊断类别的症状的机械基础。该方案具有独特的优势，能够兑现这一方法的承诺。我们试图确定一个关键的跨诊断症状的起源：持续性思维，以侵入性记忆，图像，沉思，病理性担忧或强迫性思维的形式出现。对思想的控制障碍是主要精神健康障碍中最令人痛苦的症状之一，如抑郁症，焦虑症，创伤后应激障碍和强迫症具体来说，我们将研究通过抑制控制停止检索侵入性思想的能力，我们寻求在认知，系统和电路水平上深入理解这一基本过程。我们的最终目标是在高水平认知理论和创新神经科学的推动下开发有效的治疗目标和实际干预措施，其中主要包括基于培训，药理学和脑刺激的干预措施。

项目成果

Everything you ever wanted to know about the Think/No-Think task, but forgot to ask

• DOI: 10.3758/s13428-024-02349-9
• 发表时间: 2024-02-20
• 期刊: BEHAVIOR RESEARCH METHODS
• 影响因子: 5.4
• 作者: Nardo，Davide;Anderson，Michael C.
• 通讯作者: Anderson，Michael C.

On the role of inhibition in suppression-induced forgetting.

关于抑制在抑制引起的遗忘中的作用。

• DOI: 10.1038/s41598-023-31063-3
• 发表时间: 2023-03-14
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: van Schie, Kevin;Fawcett, Jonathan M.;Anderson, Michael C.
• 通讯作者: Anderson, Michael C.

20 Reflexive downregulation of memory systems in dissociative amnesia: a case series

20 解离性遗忘症中记忆系统的反射性下调：病例系列

• DOI: 10.1136/jnnp-2023-bnpa.36
• 发表时间: 2023
• 期刊: Journal of Neurology, Neurosurgery & Psychiatry
• 作者: Marsh L

Improving mental health by training the suppression of unwanted thoughts.

• DOI: 10.1126/sciadv.adh5292
• 发表时间: 2023-09-22
• 期刊: SCIENCE ADVANCES
• 影响因子: 13.6
• 作者: Mamat, Zulkayda;Anderson, Michael C.
• 通讯作者: Anderson, Michael C.