Adaptive processing of spoken language: flexible communication in health, disease and disorder

口语的适应性处理：健康、疾病和失调中的灵活沟通

• 批准号: MC_UU_00030/6
• 负责人: Matt Davis
• 金额: $ 285.68万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00030%2F6
• 关键词: Adaptive; processing; spoken; language; flexible

Speech is the most important and complex sound that we hear every day. Impairments of speech comprehension have a devastating effect on our social and intellectual lives and are insufficiently treated by sensory prostheses (e.g. hearing aids for age-related hearing loss), or rehabilitation (e.g. speech therapy for developmental language disorders, or aphasia). To understand and ameliorate these difficulties we take inspiration from the success of healthy listeners who can achieve successful comprehension despite many everyday challenges. We comprehend speech produced with a marked accent, or heard in a noisy environment, demonstrating robustness of sensory processing. Linguistic robustness is illustrated when we correctly interpret unfamiliar words in sentences or infer the correct meaning of ambiguous words like “bark” or “bank”. The brain systems that achieve resilient speech understanding in the face of these challenges may be responsible for comprehension impairments when they are damaged. If, conversely, these brain systems remain available to impaired listeners then they may permit new forms of rehabilitation. We work with a range of clinical populations with sensory and language impairments to test these hypotheses and to develop new methods of detecting speech comprehension impairments, discovering their underlying causes and suggesting new interventions.

言语是我们每天听到的最重要、最复杂的声音。言语理解障碍对我们的社交和智力生活产生了毁灭性的影响，并且无法通过感觉假肢（例如针对与年龄有关的听力损失的助听器）或康复（例如针对发展性语言障碍或失语症的言语治疗）得到充分治疗。为了理解和改善这些困难，我们从健康听众的成功中获得灵感，他们尽管面临许多日常挑战，但仍能成功地理解。我们能够理解带有明显口音的说话，或者在嘈杂的环境中听到的声音，这表明了感官处理的稳健性。当我们正确地解释句子中不熟悉的单词或推断出“bark”或“bank”等模棱两可的单词的正确含义时，就说明了语言的稳健性。面对这些挑战，实现弹性语言理解的大脑系统可能会在受损时造成理解障碍。相反，如果这些大脑系统对受损的听众仍然可用，那么它们可能会允许新的康复形式。我们与一系列有感觉和语言障碍的临床人群合作，以测试这些假设，并开发检测语言理解障碍的新方法，发现其潜在原因并提出新的干预措施。

项目成果

Causal contributions of the domain-general (Multiple Demand) and the language-selective brain networks to perceptual and semantic challenges in speech comprehension

通用领域（多需求）和语言选择性大脑网络对语音理解中感知和语义挑战的因果贡献

• DOI: 10.1101/2022.04.12.487989
• 发表时间: 2022
• 作者: MacGregor L

A checklist for assessing the methodological quality of concurrent tES-fMRI studies (ContES checklist): a consensus study and statement.

• DOI: 10.1038/s41596-021-00664-5
• 发表时间: 2022-03
• 期刊: Nature protocols
• 影响因子: 14.8
• 作者: Ekhtiari H;Ghobadi-Azbari P;Thielscher A;Antal A;Li LM;Shereen AD;Cabral-Calderin Y;Keeser D;Bergmann TO;Jamil A;Violante IR;Almeida J;Meinzer M;Siebner HR;Woods AJ;Stagg CJ;Abend R;Antonenko D;Auer T;Bächinger M;Baeken C;Barron HC;Chase HW;Crinion J;Datta A;Davis MH;Ebrahimi M;Esmaeilpour Z;Falcone B;Fiori V;Ghodratitoostani I;Gilam G;Grabner RH;Greenspan JD;Groen G;Hartwigsen G;Hauser TU;Herrmann CS;Juan CH;Krekelberg B;Lefebvre S;Liew SL;Madsen KH;Mahdavifar-Khayati R;Malmir N;Marangolo P;Martin AK;Meeker TJ;Ardabili HM;Moisa M;Momi D;Mulyana B;Opitz A;Orlov N;Ragert P;Ruff CC;Ruffini G;Ruttorf M;Sangchooli A;Schellhorn K;Schlaug G;Sehm B;Soleimani G;Tavakoli H;Thompson B;Timmann D;Tsuchiyagaito A;Ulrich M;Vosskuhl J;Weinrich CA;Zare-Bidoky M;Zhang X;Zoefel B;Nitsche MA;Bikson M
• 通讯作者: Bikson M

Causal Contributions of the Domain-General (Multiple Demand) and the Language-Selective Brain Networks to Perceptual and Semantic Challenges in Speech Comprehension.

领域将军（多重需求）和语言选择性大脑网络的因果贡献对语音理解中的知觉和语义挑战。

• DOI: 10.1162/nol_a_00081
• 发表时间: 2022
• 期刊: NEUROBIOLOGY OF LANGUAGE
• 影响因子: 3.2
• 作者: MacGregor, Lucy J.;Gilbert, Rebecca A.;Balewski, Zuzanna;Mitchell, Daniel J.;Erzinclioglu, Sharon W.;Rodd, Jennifer M.;Duncan, John;Fedorenko, Evelina;Davis, Matthew H.
• 通讯作者: Davis, Matthew H.

Timing of brain entrainment to the speech envelope during speaking, listening and self-listening.

• DOI: 10.1016/j.cognition.2022.105051
• 发表时间: 2022-07
• 期刊: COGNITION
• 影响因子: 3.4
• 作者: Perez, Alejandro;Davis, Matthew H.;Ince, Robin A. A.;Zhang, Hanna;Fu, Zhanao;Lamarca, Melanie;Ralph, Matthew A. Lambon;Monahan, Philip J.
• 通讯作者: Monahan, Philip J.

Temporal lobe perceptual predictions for speech are instantiated in motor cortex and reconciled by inferior frontal cortex.

颞叶对言语的感知预测在运动皮层中实例化，并由下额叶皮层协调。

• DOI: 10.1016/j.celrep.2023.112422
• 发表时间: 2023
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Cope TE