Determining the bacterial contributions to tuberculosis and identification of drug targets

结核病预防中出现了严重的耐药性问题，给全球卫生系统带来巨大压力。我们已经鉴定出结核分枝杆菌的一种酶，它对结核分枝杆菌的生存至关重要。该项目将开发对该酶有效的抑制化合物。此外，我们将通过筛选来确定新的药物靶点，以明确识别生物体在体内生存所必需的基因。这些信息将用于开发新的结核病药物。

Serious issues of drug resistance have emerged in tuberculosis prevention and are placing enormous pressure on global health systems. We have identified an enzyme of M. tuberculosis that is essential for its survival. This project will develop potent inhibitory compounds for this enzyme. Further, we will identify new drug targets through a screen to specifically identify the genes of the organism essential for its survival in the body. This information will be used to develop new TB drugs.