Determining the bacterial contributions to tuberculosis and identification of drug targets

确定细菌对结核病的贡献并确定药物靶点

• 批准号: nhmrc : 1012865
• 负责人: Dr Nicholas West
• 金额: $ 29.6万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/determining-bacterial-contributions-drug-targets/109686
• 关键词: Determining; bacterial; contributions; tuberculosis; identification

Serious issues of drug resistance have emerged in tuberculosis prevention and are placing enormous pressure on global health systems. We have identified an enzyme of M. tuberculosis that is essential for its survival. This project will develop potent inhibitory compounds for this enzyme. Further, we will identify new drug targets through a screen to specifically identify the genes of the organism essential for its survival in the body. This information will be used to develop new TB drugs.

在结核病预防工作中出现了严重的耐药性问题，给全球卫生系统带来巨大压力。我们已经确定了一种酶的M。结核病是其生存所必需的。该项目将开发这种酶的有效抑制化合物。此外，我们将通过筛选来确定新的药物靶点，以专门确定生物体在体内生存所必需的基因。这些信息将用于开发新的结核病药物。