Improving subunit vaccines against tuberculosis for pulmonary delivery

结核病在全球范围内是一个巨大的健康问题，由于我们靠近高负担国家，它仍然是对澳大利亚的威胁。开发更好的结核病疫苗对于减少疾病和防止传播至关重要。我们将开发和测试新的结核病疫苗，该疫苗由保护性结核病蛋白和干粉状免疫刺激分子组成，可以安全地输送到肺部。这种可呼吸的疫苗将用于预防结核病，并增强卡介苗的效果。

Tuberculosis is an enormous health problem globally and remains a threat to Australia because of our proximity to high burden countries. The development of better vaccines against TB is crucial to reducing disease and preventing transmission. We shall develop and test new TB vaccines composed of a protective TB protein and immune-stimulating molecules in dry powder which can be safely delivered to the lungs. This respirable vaccine will be used to protect against TB and boost the effects of BCG.