Improving subunit vaccines against tuberculosis for pulmonary delivery

改进肺结核亚单位疫苗

• 批准号: nhmrc : 1044343
• 负责人: Dr Nicholas West
• 金额: $ 42.36万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/improving-subunit-vaccines-pulmonary-delivery/111653
• 关键词: Improving; subunit; vaccines; against; tuberculosis

Tuberculosis is an enormous health problem globally and remains a threat to Australia because of our proximity to high burden countries. The development of better vaccines against TB is crucial to reducing disease and preventing transmission. We shall develop and test new TB vaccines composed of a protective TB protein and immune-stimulating molecules in dry powder which can be safely delivered to the lungs. This respirable vaccine will be used to protect against TB and boost the effects of BCG.

结核病是全球一个巨大的健康问题，由于澳大利亚靠近高负担国家，结核病仍然对澳大利亚构成威胁。开发更好的结核病疫苗对于减少疾病和预防传播至关重要。我们将开发和测试由保护性结核蛋白和干粉形式的免疫刺激分子组成的新型结核疫苗，可以安全地输送到肺部。这种呼吸疫苗将用于预防结核病并增强卡介苗的效果。