Preventing the evolution of transmissible nitroimidazole resistance in Mycobacterium tuberculosis

结核病导致的死亡人数比其他任何传染病都要多。不幸的是，由于耐药性的演变，我们可用于治疗结核病的药物正在失去疗效。一种新的药物--硝基咪唑类药物已经被开发出来，但引起结核病的细菌也有可能对这些化合物产生抗药性。我们将在野生情况发生之前识别抗药性突变，以帮助识别它们，并找到无法产生抗药性的新化合物。

Tuberculosis kills more people than any other infectious disease. Unfortunately, the drugs available to us to treat TB are losing their efficacy due to the evolution of drug resistance. A new class of drugs, nitroimidazoles, has been developed, but there is a risk that the bacterium that causes TB will develop resistance to these compounds too. We will identify resistance mutations before they occur in the wild, to help identify them and find new compounds for which resistance cannot develop.