Killing infected cells as a mechanism to eradicate tuberculosis
Killing infected cells as a mechanism to eradicate tuberculosis
批准号:
nhmrc : 1147010
负责人:
Dr Nicholas West
金额:
$72.4万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2021-12-31
中文摘要
结核分枝杆菌(Mycobacterium tuberculosis,Mtb)是结核病的病原体,其对所有抗生素的耐药性正在迅速增强,每年有超过100万人死于这种疾病。这表明迫切需要开发新的治疗方法。我们正在开发一种杀死结核杆菌感染细胞的疗法,可能有助于根除感染。这种治疗结核病的非常新颖的方法将对感染这种病原体的20亿人产生深远的影响。
英文摘要
Mycobacterium tuberculosis (Mtb), the causative agent of TB, is rapidly becoming resistant to all antibiotics and this disease kills more than one million people each year. This underscores the urgent need to develop new treatments for this disease. We are developing a therapy that kills Mtb infected cells and may help to eradicate infection. This highly novel approach to the treatment of TB would have profound implications for the 2 billion people infected with this pathogen.
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会议论文
Preventing the evolution of transmissible nitroimidazole resistance in Mycobacterium tuberculosis
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批准号:nhmrc : 1139832
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项目类别:Project Grants
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资助金额:$44.93万
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财政年份:2018
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负责人:Dr Nicholas West
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依托单位:
Killing infected cells as a mechanism to eradicate tuberculosis
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批准号:nhmrc : GNT1147010
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项目类别:Project Grants
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资助金额:$107.08万
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财政年份:2018
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负责人:Dr Nicholas West
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依托单位:
Discovery of New Tuberculosis Drug Leads Targeting Cell Wall Biosynthesis
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批准号:nhmrc : GNT1082533
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项目类别:Project Grants
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资助金额:$46.16万
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财政年份:2015
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负责人:Dr Nicholas West
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依托单位:
Discovery of New Tuberculosis Drug Leads Targeting Cell Wall Biosynthesis
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批准号:nhmrc : 1082533
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项目类别:Project Grants
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资助金额:$47.66万
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财政年份:2015
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负责人:Dr Nicholas West
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依托单位:
Improving subunit vaccines against tuberculosis for pulmonary delivery
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批准号:nhmrc : 1044343
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项目类别:Project Grants
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资助金额:$42.36万
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财政年份:2013
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负责人:Dr Nicholas West
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依托单位:
Design, development and analysis of new tuberculosis drugs
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批准号:nhmrc : 1011266
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项目类别:NHMRC Project Grants
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资助金额:$49.12万
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财政年份:2011
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负责人:Dr Nicholas West
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依托单位:
Determining the bacterial contributions to tuberculosis and identification of drug targets
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批准号:nhmrc : 1012865
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项目类别:Career Development Fellowships
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资助金额:$29.6万
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财政年份:2011
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负责人:Dr Nicholas West
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依托单位:
Genome wide investigations of Mycobacterium tuberculosis to reveal processes of pathogenesis
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批准号:nhmrc : 457047
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项目类别:NHMRC Project Grants
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资助金额:$26.43万
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财政年份:2007
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负责人:Dr Nicholas West
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依托单位:
海外基金