Lifecourse Determinants of Bone and Joint Disease

骨和关节疾病的生命周期决定因素

• 批准号: MC_UU_12011/1
• 负责人: Cyrus Cooper
• 金额: $ 523.95万
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_12011%2F1
• 关键词: Lifecourse; Determinants; Bone; Joint; Disease

The mission of the MRC Lifecourse Epidemiology Unit is to provide a centre of excellence which uses epidemiological methods to promote human health by delineating the environmental and occupational causes throughout the lifecourse of: (1) chronic musculoskeletal disorders (osteoporosis, osteoarthritis and sarcopenia); and (2) metabolic disorders (diabetes mellitus, obesity and cardiovascular disease). Through understanding these causes, we aim to develop population-based and high risk preventive strategies against these disorders. This programme will explore the origins of osteoporosis and its related fractures in the elderly, as well as osteoarthritis. These are the two commonest bone and joint disorders worldwide.

医学研究理事会生命过程流行病学股的使命是提供一个英才中心，利用流行病学方法，通过确定生命过程中的环境和职业原因来促进人类健康：（1）慢性肌肉骨骼疾病（骨质疏松症、骨关节炎和肌肉减少症）;（2）代谢疾病（糖尿病、肥胖症和心血管疾病）。通过了解这些原因，我们的目标是针对这些疾病制定基于人群的高风险预防策略。本课程将探讨老年人骨质疏松症及其相关骨折的起源，以及骨关节炎。这是世界上最常见的两种骨关节疾病。

项目成果

Associations between APOE and low-density lipoprotein cholesterol genotypes and cognitive and physical capability: the HALCyon programme.

• DOI: 10.1007/s11357-014-9673-9
• 发表时间: 2014
• 期刊: AGE
• 作者: Alfred, Tamuno;Ben-Shlomo, Yoav;Cooper, Rachel;Hardy, Rebecca;Cooper, Cyrus;Deary, Ian J.;Elliott, Jane;Gunnell, David;Harris, Sarah E.;Kivimaki, Mika;Kumari, Meena;Martin, Richard M.;Power, Chris;Sayer, Avan Aihie;Starr, John M.;Kuh, Diana;Day, Ian Nm
• 通讯作者: Day, Ian Nm

Capture the Fracture: a Best Practice Framework and global campaign to break the fragility fracture cycle.

• DOI: 10.1007/s00198-013-2348-z
• 发表时间: 2013-08
• 期刊: OSTEOPOROSIS INTERNATIONAL
• 影响因子: 4
• 作者: Akesson, K.;Marsh, D.;Mitchell, P. J.;McLellan, A. R.;Stenmark, J.;Pierroz, D. D.;Kyer, C.;Cooper, C.
• 通讯作者: Cooper, C.

2019 EULAR points to consider for non-physician health professionals to prevent and manage fragility fractures in adults 50 years or older.

• DOI: 10.1136/annrheumdis-2020-216931
• 发表时间: 2021-01
• 期刊: Annals of the rheumatic diseases
• 影响因子: 27.4
• 作者: Adams J;Wilson N;Hurkmans E;Bakkers M;Balážová P;Baxter M;Blavnsfeldt AB;Briot K;Chiari C;Cooper C;Dragoi RG;Gäbler G;Lems W;Mosor E;Pais S;Simon C;Studenic P;Tilley S;de la Torre-Aboki J;Stamm TA
• 通讯作者: Stamm TA

The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation.

• DOI: 10.1038/s41467-021-22639-6
• 发表时间: 2021-05-11
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Acton RJ;Yuan W;Gao F;Xia Y;Bourne E;Wozniak E;Bell J;Lillycrop K;Wang J;Dennison E;Harvey NC;Mein CA;Spector TD;Hysi PG;Cooper C;Bell CG
• 通讯作者: Bell CG

Alendronate use and bone mineral density gains in women with moderate-severe (stages 3B-5) chronic kidney disease: an open cohort multivariable and propensity score analysis from Funen, Denmark.

• DOI: 10.1007/s11657-020-00746-z
• 发表时间: 2020-06-01
• 期刊: Archives of osteoporosis
• 影响因子: 3
• 作者: Ali MS;Ernst M;Robinson DE;Caskey F;Arden NK;Ben-Shlomo Y;Nybo M;Rubin KH;Judge A;Cooper C;Javaid MK;Hermann AP;Prieto-Alhambra D
• 通讯作者: Prieto-Alhambra D