Associations between APOE and low-density lipoprotein cholesterol genotypes and cognitive and physical capability: the HALCyon programme.
Associations between APOE and low-density lipoprotein cholesterol genotypes and cognitive and physical capability: the HALCyon programme.
复制标题
DOI：
10.1007/s11357-014-9673-9
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Day, Ian Nm
中科院分区：
文献类型：
--
作者：
Alfred, Tamuno;Ben-Shlomo, Yoav;Cooper, Rachel;Hardy, Rebecca;Cooper, Cyrus;Deary, Ian J.;Elliott, Jane;Gunnell, David;Harris, Sarah E.;Kivimaki, Mika;Kumari, Meena;Martin, Richard M.;Power, Chris;Sayer, Avan Aihie;Starr, John M.;Kuh, Diana;Day, Ian Nm
APOE ε2/3/4 基因型与低密度脂蛋白胆固醇 (LDL-C) 和阿尔茨海默病有关。然而，关于未患痴呆症的成年人的认知表现测量与身体表现的相关性的证据是混杂的。与 LDL-C 水平有关的其他基因型也可能存在明显的关联。作为整个生命周期健康老龄化 (HALCyon) 合作研究计划的一部分，从 8 组年龄在 44 岁至 90 岁以上的成年人中获得了 APOE ε2/3/4、rs515135 (APOB)、rs2228671 (LDLR) 和 rs629301 (SORT1) 的基因型信息。我们使用荟萃分析研究了四种认知指标（单词回忆、音素流畅性、语义流畅性和搜索速度）和身体能力（握力、起身和行走/行走速度、定时椅子起立和平衡能力）之间的关联。总体而言，几乎没有观察到任何基因型与认知能力测量之间存在关联的证据（例如，APOE ε4 的汇总 beta 对语义流畅性 z 得分 = −0.02 的影响；95% CI = −0.05 至 0.02；p 值 = 0.3；n = 18,796）。然而，研究中的边缘证据表明，随着年龄的增长，APOE ε4 对非语言能力测量的负面影响变得更加明显。几乎没有观察到基因型与身体能力测量的关联。我们对一般人群中的中老年人进行的大规模调查结果表明，APOE 对认知能力的影响至多是适度的，并且是特定领域和年龄的，而 APOE 对身体能力的影响很小。此外，其他 LDL-C 相关基因型对这些性状影响不大。本文的在线版本 (doi:10.1007/s11357-014-9673-9) 包含补充材料，可供授权用户使用。
The APOE ε2/3/4 genotype has been associated with low-density lipoprotein cholesterol (LDL-C) and Alzheimer disease. However, evidence for associations with measures of cognitive performance in adults without dementia has been mixed, as it is for physical performance. Associations may also be evident in other genotypes implicated in LDL-C levels. As part of the Healthy Ageing across the Life Course (HALCyon) collaborative research programme, genotypic information was obtained for APOE ε2/3/4, rs515135 (APOB), rs2228671 (LDLR) and rs629301 (SORT1) from eight cohorts of adults aged between 44 and 90 + years. We investigated associations with four measures of cognitive (word recall, phonemic fluency, semantic fluency and search speed) and physical capability (grip strength, get up and go/walk speed, timed chair rises and ability to balance) using meta-analyses. Overall, little evidence for associations between any of the genotypes and measures of cognitive capability was observed (e.g. pooled beta for APOE ε4 effect on semantic fluency z score = −0.02; 95 % CI = −0.05 to 0.02; p value = 0.3; n = 18,796). However, there was borderline evidence within studies that negative effects of APOE ε4 on nonverbal ability measures become more apparent with age. Few genotypic associations were observed with physical capability measures. The findings from our large investigation of middle-aged to older adults in the general population suggest that effects of APOE on cognitive capability are at most modest and are domain- and age-specific, while APOE has little influence on physical capability. In addition, other LDL-C-related genotypes have little impact on these traits. The online version of this article (doi:10.1007/s11357-014-9673-9) contains supplementary material, which is available to authorized users.
登录
查看更多内容
影响因子：
2.6
作者：
Bunce, David;Anstey, Kaarin J.;Easteal, Simon
通讯作者：
Easteal, Simon
影响因子：
11
作者：
Davies G;Harris SE;Reynolds CA;Payton A;Knight HM;Liewald DC;Lopez LM;Luciano M;Gow AJ;Corley J;Henderson R;Murray C;Pattie A;Fox HC;Redmond P;Lutz MW;Chiba-Falek O;Linnertz C;Saith S;Haggarty P;McNeill G;Ke X;Ollier W;Horan M;Roses AD;Ponting CP;Porteous DJ;Tenesa A;Pickles A;Starr JM;Whalley LJ;Pedersen NL;Pendleton N;Visscher PM;Deary IJ
通讯作者：
Deary IJ
影响因子：
2.4
作者：
Ihle, Andreas;Bunce, David;Kliegel, Matthias
通讯作者：
Kliegel, Matthias
DOI：
10.1093/geronb/gbn033
发表时间：
2009-01-01
影响因子：
6.2
作者：
Johnson, Wendy;Deary, Ian J.;Christensen, Kaare
通讯作者：
Christensen, Kaare
影响因子：
5.5
作者：
Clouston SA;Brewster P;Kuh D;Richards M;Cooper R;Hardy R;Rubin MS;Hofer SM
通讯作者：
Hofer SM