Programme 1: Musculoskeletal health in later life

项目 1：晚年肌肉骨骼健康

• 批准号: MC_PC_21001
• 负责人: Cyrus Cooper
• 金额: $ 426.47万
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_21001
• 关键词: Programme; Musculoskeletal; health; later; life

The aim of this programme is to reduce the burden of chronic non-communicable musculoskeletal disorders such as osteoporosis, osteoarthritis and sarcopenia (the commonest disorders worldwide of bone, joint and muscle respectively). Our approach integrates observational epidemiology and mechanistic understanding to develop novel interventions in later life aimed at optimising musculoskeletal health. Our work has already informed strategies developed by the WHO and IOF. Complemented by investigation of underlying mechanisms, we are evaluating interventions that might be widely delivered in older age, in order to successfully implement potential novel public health strategies which will reduce the health burden resulting from these disorders.

该方案的目的是减轻慢性非传染性肌肉骨骼疾病的负担，如骨质疏松症、骨关节炎和肌肉减少症（分别是世界上最常见的骨骼、关节和肌肉疾病）。我们的方法整合了观察流行病学和机械理解，以开发旨在优化肌肉骨骼健康的新干预措施。我们的工作已经为世卫组织和法语国家国际组织制定的战略提供了信息。通过对潜在机制的调查，我们正在评估可能在老年人中广泛提供的干预措施，以成功实施潜在的新公共卫生战略，减少这些疾病造成的健康负担。

项目成果

Altered H19/miR-675 expression in skeletal muscle is associated with low muscle mass in community-dwelling older adults

骨骼肌中 H19/miR-675 表达的改变与社区老年人的低肌肉质量有关

• DOI: 10.1002/rco2.44
• 发表时间: 2021
• 期刊: JCSM Rapid Communications
• 作者: Antoun E

Opportunistic diagnosis of osteoporosis, fragile bone strength and vertebral fractures from routine CT scans; a review of approved technology systems and pathways to implementation.

• DOI: 10.1177/1759720x211024029
• 发表时间: 2021
• 期刊: Therapeutic advances in musculoskeletal disease
• 影响因子: 4.2
• 作者: Aggarwal V;Maslen C;Abel RL;Bhattacharya P;Bromiley PA;Clark EM;Compston JE;Crabtree N;Gregory JS;Kariki EP;Harvey NC;Ward KA;Poole KES
• 通讯作者: Poole KES

DNA methylation signatures in cord blood associated with birthweight are enriched for dmCpGs previously associated with maternal hypertension or pre-eclampsia, smoking and folic acid intake.

• DOI: 10.1080/15592294.2021.1908706
• 发表时间: 2022-04
• 期刊: Epigenetics
• 影响因子: 3.7
• 作者: Antoun E;Titcombe P;Dalrymple K;Kitaba NT;Barton SJ;Flynn A;Murray R;Garratt ES;Seed PT;White SL;Cooper C;Inskip HM;Hanson M;Poston L;Godfrey KM;Lillycrop KA;UPBEAT Consortium/EpiGen Consortium
• 通讯作者: UPBEAT Consortium/EpiGen Consortium

The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation.

• DOI: 10.1038/s41467-021-22639-6
• 发表时间: 2021-05-11
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Acton RJ;Yuan W;Gao F;Xia Y;Bourne E;Wozniak E;Bell J;Lillycrop K;Wang J;Dennison E;Harvey NC;Mein CA;Spector TD;Hysi PG;Cooper C;Bell CG
• 通讯作者: Bell CG

Epigenome-wide association study of sarcopenia: findings from the Hertfordshire Sarcopenia Study (HSS).

• DOI: 10.1002/jcsm.12876
• 发表时间: 2022-03
• 期刊: Journal of cachexia, sarcopenia and muscle
• 作者: Antoun E;Garratt ES;Taddei A;Burton MA;Barton SJ;Titcombe P;Westbury LD;Baczynska A;Migliavacca E;Feige JN;Sydall HE;Dennison E;Dodds R;Roberts HC;Richardson P;Sayer AA;Shaw S;Cooper C;Holbrook JD;Patel HP;Godfrey KM;Lillycrop KA;EpiGen Global Research Consortium
• 通讯作者: EpiGen Global Research Consortium