Establishment of a National Network on Musculoskeletal Ageing

建立国家肌肉骨骼衰老网络

• 批准号: MC_PC_21022
• 负责人: Cyrus Cooper
• 金额: $ 19.22万
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_21022
• 关键词: Establishment; National; Network; Musculoskeletal; Ageing

Our overall aim is to establish a new national network which will underpin a step change in musculoskeletal ageing research capacity and strategy, by identifying: key tractable research priorities; developing an integrated multi-disciplinary grouping to address the identified research gaps; providing a platform to disseminate best practice; supporting Early Career Researchers (ECRs) to build research capacity and ensure longevity to current UKRI investments; and coordinating an ongoing programme of innovative studies to identify, develop and translate findings from our discovery science to clinical impact. Crucially the network will contribute to delivering the government “Grand Challenge” target of 5 more years of independent living by 2035, by identifying approaches to maintain mobility in old age. The network will bring together the scientific excellence of the three principal applicants. Focusing on the leading chronic non-communicable disorders of bone, muscle and joint (osteoporosis, sarcopenia, rheumatoid arthritis and osteoarthritis), the integration of these groups will galvanize a truly bench to bedside approach to provide a strong evidence base for health policy, underpinning a step change in UK musculoskeletal ageing research capability/capacity, and promoting increased healthspan.

我们的总体目标是建立一个新的国家网络，通过确定：关键易处理的研究优先事项，支持肌肉骨骼老化研究能力和战略的一步变化;发展一个综合的多学科小组，以解决已确定的研究差距;提供一个平台，传播最佳实践;支持早期职业研究人员（ECR）建立研究能力，并确保目前UKRI投资的寿命;并协调正在进行的创新研究计划，以确定，开发和转化我们的发现科学的临床影响的发现。至关重要的是，该网络将通过确定老年人保持流动性的方法，为实现政府到2035年再独立生活5年的“大挑战”目标做出贡献。该网络将汇集三个主要申请人的科学专长。专注于骨，肌肉和关节的主要慢性非传染性疾病（骨质疏松症，肌肉减少症，类风湿性关节炎和骨关节炎），这些团体的整合将激发一个真正的板凳到床边的方法，为卫生政策提供强有力的证据基础，支持英国肌肉骨骼老化研究能力/能力的一步变化，并促进健康寿命的增加。

项目成果

Association of Longer Leukocyte Telomere Length With Cardiac Size, Function, and Heart Failure.

• DOI: 10.1001/jamacardio.2023.2167
• 发表时间: 2023-09-01
• 期刊: JAMA cardiology
• 影响因子: 24

Measuring health-related quality of life in sarcopenia: summary of the SarQoL psychometric properties.

• DOI: 10.1007/s40520-023-02438-3
• 发表时间: 2023-08
• 期刊: AGING CLINICAL AND EXPERIMENTAL RESEARCH
• 影响因子: 4
• 作者: Beaudart, Charlotte;Reginster, Jean-Yves;Thiyagarajan, Jotheeswaran Amuthavalli;Bautmans, Ivan;Bauer, Juergen;Burlet, Nansa;Cesari, Matteo;Cherubini, Antonio;Cooper, Cyrus;Cruz-Jentoft, Alfonso J.;Dawson-Hughes, Bess;Fielding, Roger A.;Harvey, Nicholas C.;Landi, Francesco;Laslop, Andrea;Maggi, Stefania;Montero-Errasquin, Beatriz;Concepcion, Prieto Yerro Maria;Rolland, Yves;Rizzoli, Rene;Visser, Marjolein;Bruyere, Olivier
• 通讯作者: Bruyere, Olivier

Epidemiology of hip fracture in Qatar and development of a country specific FRAX model.

• DOI: 10.1007/s11657-022-01083-z
• 发表时间: 2022-03-18
• 期刊: Archives of osteoporosis
• 影响因子: 3
• 作者: Abdulla N;Alsaed OS;Lutf A;Alam F;Abdulmomen I;Al Emadi S;Harvey NC;Liu E;Vandenput L;Lorentzon M;McCloskey E;Kanis JA;Johansson H
• 通讯作者: Johansson H

Patient preferences for lifestyle behaviours in osteoporotic fracture prevention: a cross-European discrete choice experiment.

骨质疏松性骨折预防中对生活方式行为的偏好：跨欧洲离散选择实验。

• DOI: 10.1007/s00198-022-06310-4
• 发表时间: 2022-06
• 期刊: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Impact of the COVID-19 pandemic on community-dwelling older adults: A longitudinal qualitative study of participants from the Hertfordshire Cohort Study.

• DOI: 10.1371/journal.pone.0275486
• 发表时间: 2022
• 期刊: PLOS ONE
• 影响因子: 3.7
• 作者: Bloom, Ilse;Zhang, Jean;Hammond, Julia;Bevilacqua, Gregorio;Lawrence, Wendy;Ward, Kate A.;Cooper, Cyrus;Dennison, Elaine M.
• 通讯作者: Dennison, Elaine M.