MOLECULAR STRUCTURE OF ANIMAL VIRUSES AND CELLS BY COMPUTATIONAL ANALYSIS

通过计算分析动物病毒和细胞的分子结构

• 批准号: 5200950
• 负责人: J V MAIZEL
• 金额: --
• 依托单位: DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5200950
• 关键词: Adenoviridae; Picornaviridae; computer assisted sequence analysis; computer simulation; computer system design /evaluation; electron microscopy; human immunodeficiency virus; information systems; model design /development; nucleic acid sequence; parallel processing; protein sequence; virus DNA; virus RNA; virus genetics; virus protein

Infected and transformed cells are modeled using viral systems. Computers are used to study the nucleic acid and protein sequences that embody the information of living systems. Computer analyses of proteins and nucleic acids are developed and implemented in conjunction with techniques of biochemistry, virology, and electron microscopy on sequences of picornaviruses, adenoviruses, and human immunodeficiency viruses. Graphic tools are developed to display, analyze and manipulate molecular structures. Computer programs are developed locally and elsewhere for application on vector and massively parallel supercomputers, minicomputers and graphic workstations to perform sequence analysis and structure predictions. Methods to assess the significance of predictions use Monte Carlo simulations, evolutionary comparisons and biochemical data. Roles for genes and proteins are deduced by comparison with databases of sequences and structures of known function.

感染和转化的细胞使用病毒系统建模。