Epithelial morphogenesis and cell polarity

上皮形态发生和细胞极性

• 批准号: MC_UU_12018/3
• 负责人: Franck Pichaud
• 金额: $ 117.86万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_12018%2F3
• 关键词: Epithelial; morphogenesis; cell; polarity

"Epithelial cell polarity specification and maintenance is a key problem in cell biology. The vast majority of cancers in human originate from epithelia (i.e. Breast, Colon, Lung, Kidney, etc.) and a major hallmark of tumourogenesis is a progressive loss of epithelial cell polarity. We are studying this problem using the fruit fly Drosophila melanogaster, coming with an unparalleled genetic toolbox, and thus allowing us to manipulate the function of virtually every single gene present in its genome. While up to 80% of the genes associated with diseases in human are conserved in Drosophila, they are often present as one single gene, which is ideal to study a gene function, as very little redundancy is present. Using this approach, we are making significant progresses toward characterizing the molecular basis for establishing and maintaining epithelial cell polarity. This is particularly relevant for better tackling the process of tumorogenesis and metastasis, as these are characterized by a loss of epithelial cell polarity."

上皮细胞的极性规范和维护是细胞生物学中的一个关键问题。人类绝大多数癌症起源于上皮细胞(如乳房、结肠、肺、肾等)。肿瘤形成的一个主要标志是上皮细胞极性的进行性丧失。我们正在使用果蝇黑腹果蝇来研究这个问题，它带有一个无与伦比的遗传工具箱，从而使我们能够操纵其基因组中几乎每一个基因的功能。虽然高达80%的与人类疾病相关的基因在果蝇中保守，但它们通常作为单个基因存在，这是研究基因功能的理想选择，因为存在的冗余很少。使用这种方法，我们在确定建立和维持上皮细胞极性的分子基础方面取得了重大进展。这与更好地处理肿瘤发生和转移过程特别相关，因为这些过程的特征是上皮细胞极性的丧失。

项目成果

Orthodenticle Is Required for the Expression of Principal Recognition Molecules That Control Axon Targeting in the Drosophila Retina.

• DOI: 10.1371/journal.pgen.1005303
• 发表时间: 2015-06
• 期刊: PLoS genetics
• 影响因子: 4.5
• 作者: Mencarelli C;Pichaud F
• 通讯作者: Pichaud F

A combination of Notch signaling, preferential adhesion and endocytosis induces a slow mode of cell intercalation in the Drosophila retina.

Notch信号，优先粘附和内吞作用的结合诱导果蝇视网膜的细胞插入模式缓慢。

• DOI: 10.1242/dev.197301
• 发表时间: 2021-05-15
• 期刊: Development (Cambridge, England)
• 作者: Blackie L;Tozluoglu M;Trylinski M;Walther RF;Schweisguth F;Mao Y;Pichaud F
• 通讯作者: Pichaud F

Transcriptional regulation of tissue organization and cell morphogenesis: the fly retina as a case study.

组织组织和细胞形态发生的转录调控：以果蝇视网膜为例。

• DOI: 10.1016/j.ydbio.2013.09.031
• 发表时间: 2014
• 期刊: Developmental biology
• 影响因子: 2.7
• 作者: Pichaud F

RanBP1 plays an essential role in directed migration of neural crest cells during development

RanBP1 在神经嵴细胞发育过程中的定向迁移中发挥重要作用

• DOI: 10.1101/2022.05.05.490747
• 发表时间: 2022
• 作者: Barriga E

The ultrastructural organization of endoplasmic reticulum-plasma membrane contacts is conserved in epithelial cells.

• DOI: 10.1091/mbc.e21-11-0534-t
• 发表时间: 2022-10-01
• 期刊: MOLECULAR BIOLOGY OF THE CELL
• 影响因子: 3.3
• 作者: Chung, Gary Hong Chun;Lorvellec, Maelle;Gissen, Paul;Pichaud, Franck;Burden, Jemima J.;Stefan, Christopher J.
• 通讯作者: Stefan, Christopher J.